作者:Yunfei Cai、Jun Li、Weiliang Chen、Mingsheng Xie、Xiaohua Liu、Lili Lin、Xiaoming Feng
DOI:10.1021/ol3009446
日期:2012.6.1
Catalytic asymmetric sulfenylation of unprotected 3-substituted oxindoles has been developed via cooperative catalysis of a chiral N,N-dioxide-Sc(OTf)(3) complex and a Bronsted base. Utilizing readily available N-(phenylthio)phthalimide as the sulfur source, a wide range of optically active 3-phenylthiooxindoles were obtained in excellent yields with excellent enantioselectivities under mild reaction conditions.