5-(4-bromophenyl)-3-(4-nitrophenyl)-1H-pyrazole | 1233238-19-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(4-bromophenyl)-3-(4-nitrophenyl)-1H-pyrazole
• 英文别名: 3-(4-bromophenyl)-5-(4-nitrophenyl)-1H-pyrazole
• CAS: 1233238-19-1
• 化学式: C₁₅H₁₀BrN₃O₂
• 分子量: 344.167
• InChiKey: ZBQHENCJXKUWKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(4-溴苯基)-1-(4-硝基苯基)丙-2-烯-1-酮 在 sodium persulfate 、 一水合肼 作用下， 反应 2.08h， 生成 5-(4-bromophenyl)-3-(4-nitrophenyl)-1H-pyrazole
  参考文献：
  名称：

  One-Pot Synthesis of 3,5-Diphenyl-1H-pyrazoles from Chalcones and Hydrazine under Mechanochemical Ball Milling

  摘要：

  A highly efficient and environmentally friendly method has been developed for facile synthesis of 3,5-diphenyl-1H-pyrazoles under mechanochemical ball-milling conditions. The advantages of short reaction time, high efficiency, no separation of in situ generated intermediate, using cheap sodium persulfate as the oxidant, together with very simple work-up procedure, make this one-pot and solvent-free protocol a green and powerful alternative to traditional methods for the synthesis of these kinds of compounds.

  DOI：

  10.3987/com-13-12867

文献信息

• One-Pot Synthesis of 3,5-Diphenyl-1H-pyrazoles from Chalcones and Hydrazine under Mechanochemical Ball Milling
  作者：Ze Zhang、Ya-Jun Tan、Chun-Shan Wang、Hao-Hao Wu

  DOI：10.3987/com-13-12867

  日期：——

  A highly efficient and environmentally friendly method has been developed for facile synthesis of 3,5-diphenyl-1H-pyrazoles under mechanochemical ball-milling conditions. The advantages of short reaction time, high efficiency, no separation of in situ generated intermediate, using cheap sodium persulfate as the oxidant, together with very simple work-up procedure, make this one-pot and solvent-free protocol a green and powerful alternative to traditional methods for the synthesis of these kinds of compounds.