N-[(1R,2S)-2-羟基环己基]甲磺酰胺 | 187337-05-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: N-[(1R,2S)-2-羟基环己基]甲磺酰胺
• 英文名称: N-mesylaminocyclohexan-2-ol
• 英文别名: N-[(1R,2S)-2-Hydroxycyclohexyl]methanesulfonamide
• CAS: 187337-05-9
• 化学式: C₇H₁₅NO₃S
• 分子量: 193.267
• InChiKey: IMERQFYKRPXONQ-RQJHMYQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ((1R,2S)-2-Hydroxy-cyclohexyl)-carbamic acid ethyl ester 生成 N-[(1R,2S)-2-羟基环己基]甲磺酰胺
  参考文献：
  名称：

  二烯基硅烷的不对称氨基羟基化。氨基环糖醇的有效途径

  摘要：

  甲硅烷基2,5-环己二烯的无尖锐的不对称氨基羟基化反应发生，具有完全的区域和非对映异构控制。还观察到高达68％ee的对映选择性。描述了该方法在氨基-环醇的相关实例的合成中的应用。

  DOI：

  10.1016/s0040-4039(97)00079-8

文献信息

• Organic Compounds
  申请人：Bruce Ian

  公开号：US20090163463A1

  公开（公告）日：2009-06-25

  The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R 1 , R 2 , Ar′, A and B are defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.

  本发明涉及式(I)的化合物或其盐，适宜的是药学上可接受的盐或其溶剂，其中R1、R2、Ar'、A和B基团在说明书中有定义，以及所述化合物在治疗通过抑制磷脂酰肌醇3-激酶改善的疾病中的组合物和用途。
• Desymmetrization of Cyclohexadienylsilanes. Regio-, Diastereo-, and Enantioselective Access to Sugar Mimics
  作者：Rémy Angelaud、Odile Babot、Trevor Charvat、Yannick Landais

  DOI：10.1021/jo991225z

  日期：1999.12.1

  Desymmetrization of cyclohexadienylsilanes available from Birch reduction of the corresponding arylsilanes is efficiently carried out using Sharpless asymmetric dihydroxylation and aminohydroxylation. Complete diastereocontrol and reasonable enantiocontrol have been attained during the preparation of the desired diols. An excellent regiocontrol has also been observed during aminohydroxylation of dienylsilanol 6b. The resulting diol 8 and hydroxycarbamate 27 have then been elaborated further, offering a straightforward access to various types of cyclitols, aminocyclitols, carbasugars, as well as the antibiotic palitantine 4. The complete functionalization of the original arylsilanes 5 is thus typically achieved in fewer than eight steps with high stereoselectivities and excellent overall yield.
• Rudolph, Joachim; Sennhenn, Peter C.; Vlaar, Cornelis P., Angewandte Chemie, 1996, vol. 108, # 23/24, p. 2991 - 2995
  作者：Rudolph, Joachim、Sennhenn, Peter C.、Vlaar, Cornelis P.、Sharpless, K. Barry

  DOI：——

  日期：——
• PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS
  申请人：Novartis AG

  公开号：EP2173722B1

  公开（公告）日：2012-08-29
• US8263585B2
  申请人：——

  公开号：US8263585B2

  公开（公告）日：2012-09-11