O-(5-methyl-2-nonyl-1,3-dioxan-5-ylmethyl)[bis(diethylamido)]phosphite | 1156505-23-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O-(5-methyl-2-nonyl-1,3-dioxan-5-ylmethyl)[bis(diethylamido)]phosphite
• CAS: 1156505-23-5
• 化学式: C₂₃H₄₉N₂O₃P
• 分子量: 432.627
• InChiKey: QMZODKZSWJKZNO-UHFFFAOYSA-N

物化性质

• 沸点：
  477.9±43.0 °C(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.43
• 重原子数：
  29.0
• 可旋转键数：
  17.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  34.17
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  O-(5-methyl-2-nonyl-1,3-dioxan-5-ylmethyl)[bis(diethylamido)]phosphite 以 苯 为溶剂， 反应 6.0h， 以0.92 g的产率得到O-(5-methyl-2-nonyl-1,3-dioxan-5-ylmethyl)[bis(diethylamido)]phosphate
  参考文献：
  名称：

  Synthesis of acetal and phosphocyclic methriolipids

  摘要：

  The first representatives of acetal and phosphocyclic lipids based on methriol (2-hydroxymethyl-2-methyl-1,3-propanediol) were synthesized. The interaction of the starting triol with higher aldehydes gave the corresponding alkylidene compounds, which were subsequently phosphorylated by derivatives of phosphorous acid. The intermediate amidophosphites were treated without isolation with iodobenzene, sulfur, or selenium to give phosphoacetals and their thio- and selenoanalogues, which are acetal phospholipids. Methriol bicyclophosphite was also used in the lipid synthesis. It was acylated with palmitoyl chloride at one of the bicyclic oxygen atoms. Alcoholysis of acyl polyol chlorophosphite resulted in a phospholipid, which was oxidized with sulfur to give thionphosphate.

  DOI：

  10.1134/s1068162008060149
• 作为产物：
  描述：

  双(二乙基氨基)氯膦 、 5-hydroxymethyl-5-methyl-2-nonyl-1,3-dioxane 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 O-(5-methyl-2-nonyl-1,3-dioxan-5-ylmethyl)[bis(diethylamido)]phosphite
  参考文献：
  名称：

  Synthesis of acetal and phosphocyclic methriolipids

  摘要：

  The first representatives of acetal and phosphocyclic lipids based on methriol (2-hydroxymethyl-2-methyl-1,3-propanediol) were synthesized. The interaction of the starting triol with higher aldehydes gave the corresponding alkylidene compounds, which were subsequently phosphorylated by derivatives of phosphorous acid. The intermediate amidophosphites were treated without isolation with iodobenzene, sulfur, or selenium to give phosphoacetals and their thio- and selenoanalogues, which are acetal phospholipids. Methriol bicyclophosphite was also used in the lipid synthesis. It was acylated with palmitoyl chloride at one of the bicyclic oxygen atoms. Alcoholysis of acyl polyol chlorophosphite resulted in a phospholipid, which was oxidized with sulfur to give thionphosphate.

  DOI：

  10.1134/s1068162008060149