Tert-butyl 2-oxoazecane-1-carboxylate | 458528-24-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tert-butyl 2-oxoazecane-1-carboxylate
• 英文别名: tert-butyl 2-oxoazecane-1-carboxylate
• CAS: 458528-24-0
• 化学式: C₁₄H₂₅NO₃
• 分子量: 255.357
• InChiKey: NIUDRRYJSNYFKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tert-butyl 2-oxoazecane-1-carboxylate 在 吡啶 、 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 生成 Tert-butyl 2-trimethylsilyloxyazecane-1-carboxylate
  参考文献：
  名称：

  The versatile conversion of lactams to the α-alkylated azacycles via cyclic N,O-acetal TMS ether

  摘要：

  The efficient preparation of the cyclic N,O-acetals from lactams by DIBAL reduction followed by direct trapping of the resulting N,O-hemiacetals using TMSOTf/pyridine system is described. In addition, the facile nucleophilic addition of various carbon nucleophiles at the carbonyl carbons of the lactams through the corresponding N,O-acetals is also reported. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)00459-8
• 作为产物：
  描述：

  (6E)-2,3,4,5,8,9-hexahydro-1H-azecin-10-one 在 palladium on activated charcoal 正丁基锂 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 Tert-butyl 2-oxoazecane-1-carboxylate
  参考文献：
  名称：

  The versatile conversion of lactams to the α-alkylated azacycles via cyclic N,O-acetal TMS ether

  摘要：

  The efficient preparation of the cyclic N,O-acetals from lactams by DIBAL reduction followed by direct trapping of the resulting N,O-hemiacetals using TMSOTf/pyridine system is described. In addition, the facile nucleophilic addition of various carbon nucleophiles at the carbonyl carbons of the lactams through the corresponding N,O-acetals is also reported. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)00459-8

文献信息

• The versatile conversion of lactams to the α-alkylated azacycles via cyclic N,O-acetal TMS ether
  作者：Young-Ger Suh、Seok-Ho Kim、Jae-Kyung Jung、Dong-Yun Shin

  DOI：10.1016/s0040-4039(02)00459-8

  日期：2002.4

  The efficient preparation of the cyclic N,O-acetals from lactams by DIBAL reduction followed by direct trapping of the resulting N,O-hemiacetals using TMSOTf/pyridine system is described. In addition, the facile nucleophilic addition of various carbon nucleophiles at the carbonyl carbons of the lactams through the corresponding N,O-acetals is also reported. (C) 2002 Published by Elsevier Science Ltd.