| 275365-13-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 275365-13-4
• 化学式: C₃₀H₃₇Cl₃N₂O₁₄S
• 分子量: 788.054
• InChiKey: YEORRGUGHXLVLP-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 溶剂黄146 、 锌 作用下， 以 四氢呋喃 、 溶剂黄146 为溶剂， 反应 3.17h， 生成 4-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid 2-methanesulfonyl-ethyl ester
  参考文献：
  名称：

  Synthesis of a linear α-hydroxymethyl-pentapyrrole derivative and its cyclization to uroporphyrinogens

  摘要：

  A linear pentapyrrole bearing alpha-hydroxymeythyl group in the terminal was synthesized by the stepwise coupling of alpha-free pyrrole with azafulvenium ion 6. When it was treated with a catalytic amount of p-toluensulfonic acid under anaerobic condition, followed by aerial oxidation of the products, a statistical mixture of uroporphyrin I-IV octamethyl eaters was obtained. It is proposed that this transformation proceeds through a spiro-pyrrolenine as a key intermediate. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00293-8
• 作为产物：
  描述：

  4-(2-Methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid 2-methanesulfonyl-ethyl ester 、 5-(Benzothiazol-2-ylsulfanylmethyl)-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid 2,2,2-trichloro-ethyl ester 在 disodium hydrogenphosphate 、 silver trifluoromethanesulfonate 作用下， 以 苯 为溶剂， 反应 0.17h， 以97.3%的产率得到
  参考文献：
  名称：

  Synthesis of a linear α-hydroxymethyl-pentapyrrole derivative and its cyclization to uroporphyrinogens

  摘要：

  A linear pentapyrrole bearing alpha-hydroxymeythyl group in the terminal was synthesized by the stepwise coupling of alpha-free pyrrole with azafulvenium ion 6. When it was treated with a catalytic amount of p-toluensulfonic acid under anaerobic condition, followed by aerial oxidation of the products, a statistical mixture of uroporphyrin I-IV octamethyl eaters was obtained. It is proposed that this transformation proceeds through a spiro-pyrrolenine as a key intermediate. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00293-8