[4-[3-[4-methyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid | 500581-65-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [4-[3-[4-methyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid
• 英文别名: 2-[2-Methyl-4-[3-[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]propanoyl]phenoxy]acetic acid
• CAS: 500581-65-7
• 化学式: C₂₃H₂₀F₃NO₄S
• 分子量: 463.477
• InChiKey: ZYHBYTDUOAUDSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Thia-and oxazoles and their use as ppars activators
  申请人：——

  公开号：US20040102493A1

  公开（公告）日：2004-05-27

  A compound of formula (I) or pharmaceutically acceptable salts and solvates thereof. R 1 and R 2 are independently H or C 1-3 alkyl, m is 0-3; X 1 is NH, NCH 3 , O, S; R 3 , R 4 and R 5 are independently H, CH 3 , CF 3 , OCH 3 , allyl or halogen; X 2 is (CR 10 R 11 )n wherein n is 1 or 2; R 10 and R 11 independently represent H, fluorine or C 1-16 alkyl; R 26 and R 27 are independently H, C 1-3 alkyl or R 26 and R 27 together with the carbon atom to which they are bonded form a 3-5 membered cycloalklyl ring. R 6 and R 7 independently represent H, fluorine or C 1-16 alkyl; R 9 is C 1-6 alkyl or CF 3 ; One of Y and Z is N, the other is S or O; Each R 8 independently represents CF 3 , OCH 3 , CH 3 or halogen; y is O, 1, 2, 3, 4, 5. Use of a compound of formula (I) for the manufacture of a medicament for the prevention or treatment of a hPPAR mediated disease or condition, such as dyslipidemia, syndrome X, heart failure, hypercholesteremia, cardiovascular disease, type II diabetes mellitus, type 1 diabetes, insulin resistance hyperlipidemia, obesity, anorexia bulimia, inflammation and anorexia nervosa. 1

  一种具有化学式（I）或其药学上可接受的盐和溶剂的化合物。R1和R2独立地表示H或C1-3烷基，m为0-3；X1为NH、N 、O、S；R3、R4和R5独立地表示H、CH3、CF3、O 、烯丙基或卤素；X2为（CR10R11）n，其中n为1或2；R10和R11独立地表示H、氟或C1-16烷基；R26和R27独立地表示H、C1-3烷基或R26和R27与它们结合的碳原子一起形成3-5环的环烷基环。R6和R7独立地表示H、氟或C1-16烷基；R9为C1-6烷基或 ；Y和Z中的一个为N，另一个为S或O；每个R8独立地表示 、O 、 或卤素；y为O、1、2、3、4、5。使用具有化学式（I）的化合物制备用于预防或治疗hPPAR介导的疾病或症状的药物，例如脂质代谢异常、X综合征、心力衰竭、高胆固醇血症、心血管疾病、2型糖尿病、1型糖尿病、胰岛素抵抗性高脂血症、肥胖、厌食症、炎症和神经性厌食症。
• Activator of peroxisome proliferator-activated receptor
  申请人：Sakuma Shogo

  公开号：US20050054674A1

  公开（公告）日：2005-03-10

  A compound represented by the following general formula (I): (wherein R 1 represents phenyl, etc. which can have substituents selected from the group consisting of C 1-8 alkyl, C 1-8 alkyl having halogen, halogen, hydroxyl, etc.; R 2 represents C 1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C 1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R 3 , R 4 , and R 5 each represents hydrogen, C 1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R 6 and R 7 each represents hydrogen, C 1-8 alkyl, etc.; and R 8 represents hydrogen or C 1-8 alkyl; provided that at least one of R 3 , R 4 , and R 5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.

  以下是一种由下列通式(I)表示的化合物：（其中R1代表苯基等，可以具有选择自C1-8烷基，具有卤素的C1-8烷基，卤素，羟基等的取代基; R2代表C1-8烷基等; A代表氧，硫等; X代表C1-8烷基链等; Y代表C（═O），CH═CH等; R3，R4和R5各代表氢，C1-8烷基等; B代表CH或氮; Z代表氧或硫; R6和R7各代表氢，C1-8烷基等; R8代表氢或C1-8烷基; 前提是R3、R4和R5中至少有一个不是氢）或该化合物的盐；以及包含该化合物或盐作为活性成分的PPAR-δ激动剂。
• Activator of peroxisome proliferator-activated receptor delta
  申请人：Sakuma Shogo

  公开号：US20080009525A1

  公开（公告）日：2008-01-10

  A compound represented by the following general formula (I): (wherein R 1 represents phenyl, etc. which can have substituents selected from the group consisting of C 1-8 alkyl, C 1-8 alkyl having halogen, halogen, hydroxyl, etc.; R 2 represents C 1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C 1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R 3 , R 4 , and R 5 each represents hydrogen, C 1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R 6 and R 7 each represents hydrogen, C 1-8 alkyl, etc.; and R 8 represents hydrogen or C 1-8 alkyl; provided that at least one of R 3 , R 4 , and R 5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.

  以下是通式(I)所代表的化合物（其中R1代表苯基等，可具有选自C1-8烷基，带有卤素的C1-8烷基，卤素，羟基等取代基；R2代表C1-8烷基等；A代表氧，硫等；X代表C1-8亚烷基链等；Y代表C（═O），CH═CH等；R3，R4和R5各代表氢，C1-8烷基等；B代表CH或氮；Z代表氧或硫；R6和R7各代表氢，C1-8烷基等；R8代表氢或C1-8烷基；但至少其中之一的R3，R4和R5不是氢）或该化合物的盐；以及以该化合物或盐作为活性成分的PPAR-δ激动剂。
• Activator for peroxisome proliferator-activated receptor delta
  申请人：Sakuma Shogo

  公开号：US20080009631A1

  公开（公告）日：2008-01-10

  A compound represented by the following general formula (I): (wherein R 1 represents phenyl, etc. which can have substituents selected from the group consisting of C 1-8 alkyl, C 1-8 alkyl having halogen, halogen, hydroxyl, etc.; R 2 represents C 1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C 1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R 3 , R 4 , and R 5 each represents hydrogen, C 1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R 6 and R 7 each represents hydrogen, C 1-8 alkyl, etc.; and R 8 represents hydrogen or C 1-8 alkyl; provided that at least one of R 3 , R 4 , and R 5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.

  以下是一种由下列通式（I）表示的化合物：（其中，R1代表苯基等，可以具有选自C1-8烷基，具有卤素的C1-8烷基，卤素，羟基等的取代基; R2代表C1-8烷基等; A代表氧，硫等; X代表C1-8烷基链等; Y代表C(═O)，CH═CH等; R3、R4和R5各代表氢，C1-8烷基等; B代表CH或氮; Z代表氧或硫; R6和R7各代表氢，C1-8烷基等; R8代表氢或C1-8烷基; 前提是R3、R4和R5中至少有一个不是氢）或该化合物的盐;以及包含该化合物或盐作为活性成分的PPAR-δ激动剂。
• ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR DELTA
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：EP1424330B1

  公开（公告）日：2011-09-28