Adrixetinib | 2394874-66-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Adrixetinib
• 英文别名: N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-1-propyl-4-(2,2,2-trifluoroethoxy)pyrazole-3-carboxamide
• CAS: 2394874-66-7
• 化学式: C₂₅H₂₄F₃N₅O₅
• 分子量: 531.5
• InChiKey: BWUUJXXFCSYLFW-UHFFFAOYSA-N

文献信息

• QUINOLINE DERIVATIVES AS INHIBITORS OF AXL/MER RTK AND CSF1R
  申请人：QURIENT CO., LTD.

  公开号：US20210163448A1

  公开（公告）日：2021-06-03

  The present invention relates to quinoline derivatives which are inhibitors for Axl/Mer RTK (receptor tyrosine kinase) and CSF1R (colony stimulating factor 1 receptor). These compounds are suitable for the treatment of disorders associated with, accompanied by, caused by or induced by Axl/Mer RTK and CSF1R, in particular a hyperfunction thereof. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly immune-suppressive cancer (such as those cancers with an immunosuppression of innate immunity in a tumor microenvironment (TME), refractory cancer and cancer metastases. They are also useful in the treatment of inflammatory diseases and/or neurodegenerative diseases.