isobutylidene-succinic acid diethyl ester | 132631-33-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: isobutylidene-succinic acid diethyl ester
• 英文别名: 4-Methyl-penten-(2)-dicarbonsaeure-(1.2)-diaethylester；Isobutyliden-bernsteinsaeure-diaethylester；diethyl (2Z)-2-(2-methylpropylidene)butanedioate
• CAS: 132631-33-5
• 化学式: C₁₂H₂₀O₄
• 分子量: 228.288
• InChiKey: NNEYLXDJQVJQPQ-YFHOEESVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  isobutylidene-succinic acid diethyl ester 在 palladium on activated charcoal 、 lithium aluminium tetrahydride 、 乙醚 、 乙醇 作用下， 生成 2-isobutyl-1,4-butanediol
  参考文献：
  名称：

  Overberger; Roberts, Journal of the American Chemical Society, 1949, vol. 71, p. 3621

  摘要：

  DOI：
• 作为产物：
  描述：

  O，O’－二乙基－（2－琥珀酸二乙酯基）膦酸酯 、 异丁醛 在 sodium hydride 作用下， 生成 isobutylidene-succinic acid diethyl ester
  参考文献：
  名称：

  Dhokte; Rao, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1990, vol. 29, # 12, p. 1089 - 1091

  摘要：

  DOI：

文献信息

• A New Approach to the Synthesis of Diethyl 2,3-Diisobutylsuccinate, a Component of Titanium–Magnesium Catalysts for Propylene Polymerization
  作者：I. V. Nechepurenko、I. Ya. Mainagashev、A. A. Barabanov、S. A. Sergeev、G. D. Bukatov、V. A. Zakharov、M. A. Mats’ko、K. P. Volcho、N. F. Salakhutdinov

  DOI：10.1134/s1070427221060033

  日期：2021.6

  hydrogenation of the sum of dienes. Diethyl 2,3-diisobutylsuccinate of 75–99% purity was prepared by this procedure in a good yield. The use of the synthesized diethyl 2,3-diisobutylsuccinate as a stereoregulating component of titanium–magnesium catalysts allows synthesis of polypropylene with broad molecular-mass distribution. The catalysts prepared using >95% pure diethyl 2,3-diisobutylsuccinate have the

  摘要 开发了一种通过琥珀酸二酯与两个异丁醛分子缩合，然后酯化和氢化二烯总和来制备 2,3-二烷基取代的琥珀酸酯的方法。通过该程序以良好的收率制备了纯度为 75-99% 的 2,3-二异丁基琥珀酸二乙酯。使用合成的 2,3-二异丁基琥珀酸二乙酯作为钛-镁催化剂的立体调节组分，可以合成具有宽分子量分布的聚丙烯。使用纯度 > 95% 的 2,3-二异丁基琥珀酸二乙酯制备的催化剂具有最好的特性，可以以高产率制备具有高全同立构指数的聚丙烯。
• Process for preparing alkylidene substituted succinic acid esters
  申请人：——

  公开号：US20030181743A1

  公开（公告）日：2003-09-25

  A process for the preparation of alkylidene substituted succinates comprising a step (a) in which is carried out the reaction of a carbonilic compound, a succinic and a base in a reaction medium and a step (b) in which the alkylidene substituted product obtained in (a) is esterified, characterized in that the succinic ester is used in a molar amount substantially equal to, or lower than, the amount of compound carbonilic compound, (ii) the base is used in a molar amount substantially equal to the succinic ester and is selected from metal hydrides and metal and alkoxides, and (iii) the reaction medium comprises an aprotic liquid medium or a protic liquid medium having a Ka, measured in water, lower than that of iPrOH.

  一种制备烷基亚烯替代琥珀酸盐的方法，包括步骤(a)中在反应介质中进行碳酰化合物、琥珀酸和碱的反应，以及步骤(b)中酯化得到的烷基亚烯替代产物，其特征在于琥珀酸酯的摩尔量基本等于或低于碳酰化合物的摩尔量，碱的摩尔量基本等于琥珀酸酯的摩尔量，并且选择自金属氢化物和金属、烷氧化物，反应介质包括无极性液体介质或具有在水中测得的Ka值低于iPrOH的极性液体介质。
• [EN] PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES<br/>[FR] PROCEDE DE PREPARATION DE DERIVES 1,4-DIONS SUBSTITUES PAR ALKYLIDENE
  申请人：BASELL POLIOLEFINE SPA

  公开号：WO2004014838A1

  公开（公告）日：2004-02-19

  A process for the preparation of a monoalkylidene substituted 1,4-dions derivatives of formula (Ia) or (Ib) or a mixture of (Ia) and (Ib): wherein: R1, R2 and R3, equal to or different from each other, are hydrogen atoms or C1-C20 hydrocarbon groups: T1 and T2, equal to or different from each other, are OR4. R4, NR42, SR4 or PR42; or T1 and T2 can be fused in an oxygen atom or a NR4 group; said process comprises the step of reacting a compound of formula (II), with a compound of formula (IIIa) or (IIIb), in the presence of at least one equivalent with respect to the compound of formula (IIIa) or (IIIb) of a salts of a base or a neutral base at a temperature higher than 70°C.

  一种制备式(Ia)或(Ib)或(Ia)和(Ib)混合物的单烷基亚甲基取代的1,4-二酮衍生物的方法，其中：R1、R2和R3，相互相等或不同，是氢原子或C1-C20烃基；T1和T2，相互相等或不同，是OR4，R4、NR42、SR4或PR42；或T1和T2可以在一个氧原子或一个NR4基团中融合；所述方法包括在高于70°C的温度下，在化合物(II)和化合物(IIIa)或(IIIb)的存在下，与至少相对于化合物(IIIa)或(IIIb)的一个碱盐或中性碱的当量反应。
• [EN] PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES<br/>[FR] PROCEDE PERMETTANT LA PREPARATION DE DERIVES 1,4 DIONES A SUBSTITUTION ALKYLIDENE
  申请人：BASEL POLIOLEFINE ITALIA S P A

  公开号：WO2004014839A1

  公开（公告）日：2004-02-19

  A process for the preparation of a monoalkylidene substituted 1,4-dions derivatives of formula (Ia) or (Ib) or a mixture of (Ia) and (Ib): wherein: R1, R2 and R3, equal to or different from each other, are hydrogen atoms or C1-C20 hydrocarbon groups: T1 and T2, equal to or different from each other, are OR4, R4, NR42, SR4 or PR42; or T1 and T2 can be fused in an oxygen atom or a NR4 group; said process comprises the step of reacting a compound of formula (II) with a compound of formula (IIIa) or (IIIb) in the presence of at least one equivalent with respect to the compound of formula (IIIa) or (IIIb) of a carbonate of metal M or of a compound of formula MTj such as K2C03 or KHC03.

  一种制备公式(Ia)或(Ib)或(Ia)和(Ib)混合物的单烷基亚甲基取代的1,4-二酮衍生物的方法，其中：R1、R2和R3相同或不同，是氢原子或C1-C20烃基；T1和T2相同或不同，是OR4、R4、NR42、SR4或PR42；或T1和T2可以融合在一个氧原子或NR4基团中；所述方法包括将公式(II)的化合物与公式(IIIa)或(IIIb)的化合物在至少相对于公式(IIIa)或(IIIb)的一个等当量的金属M的碳酸盐或MTj的化合物（如K2C03或KHC03）存在下反应的步骤。
• Process for preparing alkylidene-substituted-1, 4-dions derivatives
  申请人：Gulevich V Yuri

  公开号：US20050080290A1

  公开（公告）日：2005-04-14

  A process for the preparation of an monoalkylidene substituted 1,4-dions derivatives of formula (Ia) or (Ib) or a mixture of (Ia) and (Ib): wherein: R 1 , R 2 and R 3 , equal to or different from each other, are hydrogen atoms or C 1 -C 20 hydrocarbon groups: T 1 and T 2 , equal to or different from each other, are OR 4 . R 4 , NR 4 2 , SR 4 or PR 4 2 ; or T 1 and T 2 can be fused in an oxygen atom or a NR 4 group; said process comprises the step of reacting a compound of formula (II), with a compound of formula (IIIa) or (IIIb), in the presence of at least one equivalent with respect to the compound of formula (IIIa) or (IIIb) of a salts of a base or a neutral base at a temperature higher than 70 ° C.

  一种制备式(Ia)或(Ib)或(Ia)和(Ib)混合物的单亚烷基取代的 1,4-二酮衍生物的工艺： 式中R 1 , R 2 和 R 3 相互相等或不同，为氢原子或 C 1 -C 20 烃基：T 1 和 T 2 相等或不同，为 OR 4 .R 4 、NR 4 2 、SR 4 或 PR 4 2 或 T 1 和 T 2 可以融合在一个氧原子或一个 NR 4 基团；所述工艺包括以下步骤：在至少一种等同于式 (IIIa) 或 (IIIb) 化合物的碱或中性碱的盐存在下，使式 (II) 化合物与式 (IIIa) 或 (IIIb) 化合物在高于以下温度下反应 70 ° C.