2-((1S)-1-carboxy-5-methyl-bicyclo[3.3.1]non-2exo-yl)-2-methyl-propionic acid-anhydride | 3878-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 2-((1S)-1-carboxy-5-methyl-bicyclo[3.3.1]non-2exo-yl)-2-methyl-propionic acid-anhydride
• 英文别名: 2-((1S)-1-carboxy-5-methyl-bicyclo[3.3.1]non-2exo-yl)-2-methyl-propionic acid-anhydride；2-((1S)-1-Carboxy-5-methyl-bicyclo[3.3.1]non-2exo-yl)-2-methyl-propionsaeure-anhydrid
• CAS: 3878-00-0
• 化学式: C₁₅H₂₂O₃
• 分子量: 250.338
• InChiKey: WEOHCJSPFUBDAI-VQISRLSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.07
• 重原子数：
  18.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  43.37
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  ethyl magnesium iodide 、 乙醚 、 2-((1S)-1-carboxy-5-methyl-bicyclo[3.3.1]non-2exo-yl)-2-methyl-propionic acid-anhydride 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Erdheim-Chester syndrome, presenting as hypogonadotropic hypogonadism and diabetes insipidus

  摘要：

  Erdheim-Chester syndrome is a rare multisystem disease in which progressive xanthogranulomatous infiltration of several tissues are seen. Knee and leg pain are the most common symptoms and bilateral symmetric sclerosis of metaphyseal region of long bones of the lower extremity is typical. Histologically, it resembles Langerhans cell histiocytosis (LCH). However, it is still a matter of discussion whether Erdheim-Chester syndrome is a distinct entity or a type of LCH. The present case is a 46-yr-old man, that presented with signs and symptoms of diabetes insipidus and hypogonadotropic hypogonadism simultaneously. X-rays and bone scintigraphy showed typical and pathogonomic findings of Erdheim-Chester syndrome. Bone biopsy and immunohistochemical staining strongly support the diagnosis of non-Langerhans cell histiocytosis.

  DOI：

  10.1007/bf03345108
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 2-((1S)-1-carboxy-5-methyl-bicyclo[3.3.1]non-2exo-yl)-2-methyl-propionic acid-anhydride
  参考文献：
  名称：

  Erdheim-Chester syndrome, presenting as hypogonadotropic hypogonadism and diabetes insipidus

  摘要：

  Erdheim-Chester syndrome is a rare multisystem disease in which progressive xanthogranulomatous infiltration of several tissues are seen. Knee and leg pain are the most common symptoms and bilateral symmetric sclerosis of metaphyseal region of long bones of the lower extremity is typical. Histologically, it resembles Langerhans cell histiocytosis (LCH). However, it is still a matter of discussion whether Erdheim-Chester syndrome is a distinct entity or a type of LCH. The present case is a 46-yr-old man, that presented with signs and symptoms of diabetes insipidus and hypogonadotropic hypogonadism simultaneously. X-rays and bone scintigraphy showed typical and pathogonomic findings of Erdheim-Chester syndrome. Bone biopsy and immunohistochemical staining strongly support the diagnosis of non-Langerhans cell histiocytosis.

  DOI：

  10.1007/bf03345108

文献信息

• 312. The chemistry of the caryophyllene series. Part IV. Clovene and clovenic acid
  作者：Robert David Blair

  DOI：10.1039/jr9350001297

  日期：——