N-<4-amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate | 107716-41-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: N-<4-amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate
• 英文别名: (2S)-2-[[4-[2-[(2-amino-6-methyl-4-oxo-1H-pyrimidin-5-yl)-[[1-[(2R,4S,5R)-4-hydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]methyl]amino]ethylamino]benzoyl]amino]pentanedioic acid
• CAS: 107716-41-6
• 化学式: C₂₉H₃₇N₈O₁₄P
• 分子量: 752.632
• InChiKey: WJMIBUYERCQKCS-UWHLTILDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.57
• 重原子数：
  52.0
• 可旋转键数：
  17.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  341.82
• 氢给体数：
  10.0
• 氢受体数：
  15.0

反应信息

• 作为产物：
  描述：

  diethyl N-<4-benzoyl>-L-glutamate 在 sodium hydroxide 、 氢溴酸 、 铜 、 碳酸氢钠 、 乙酰丙酮 、 锌 、 苯酚 作用下， 以 吡啶 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 104.0h， 生成 N-<4-amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate
  参考文献：
  名称：

  A pyrimidine-based "flexible" bisubstrate analog inhibitor of human thymidylate synthase

  摘要：

  The synthesis and characterization of two "flexible" bisubstrate analogues of the intermediate in the thymidylate synthase reaction are reported. Steric constraints are minimized and diasteromeric mixtures avoided by using a pyrimidine-based analogue as the folate portion of the inhibitor while retaining all known important binding sites. A preliminary assessment of certain conformational parameters by NMR is presented. The compounds are shown to be potent competitive inhibitors with respect to dUMP or 5,10-CH2-H4PteGlu but gave mixed kinetics with respect to 5,10-CH2-H4PteGlu5 for human thymidylate synthase.

  DOI：

  10.1021/jm00119a012

文献信息

• A pyrimidine-based "flexible" bisubstrate analog inhibitor of human thymidylate synthase
  作者：In Young Yang、R. Mark Slusher、Arthur D. Broom、T. Ueda、Yung Chi Cheng

  DOI：10.1021/jm00119a012

  日期：1988.11

  The synthesis and characterization of two "flexible" bisubstrate analogues of the intermediate in the thymidylate synthase reaction are reported. Steric constraints are minimized and diasteromeric mixtures avoided by using a pyrimidine-based analogue as the folate portion of the inhibitor while retaining all known important binding sites. A preliminary assessment of certain conformational parameters by NMR is presented. The compounds are shown to be potent competitive inhibitors with respect to dUMP or 5,10-CH2-H4PteGlu but gave mixed kinetics with respect to 5,10-CH2-H4PteGlu5 for human thymidylate synthase.