4,5-Dimethyl-3-hydroxy-cyclopentanon | 24810-61-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,5-Dimethyl-3-hydroxy-cyclopentanon
• 英文别名: 4-Hydroxy-2,3-dimethylcyclopentan-1-one
• CAS: 24810-61-5
• 化学式: C₇H₁₂O₂
• 分子量: 128.171
• InChiKey: LQFQOTBIQLUKMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Cathartic composition
  申请人：Sucampo AG

  公开号：EP1857105A2

  公开（公告）日：2007-11-21

  An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in a ratio of bi-cyclic/monocyclic structure of at least 1 : 1. The halogenated-bi-cyclic compound is represented by Formula (I): where X1 and X2 are preferably both fluorine atoms. The composition can be used to treat constipation without substantive side-effects, such as stomachache.

  本发明的目的是提供一种含有卤代双环化合物作为活性成分的抗便秘组合物，其双环/单环结构的比例至少为 1:1。卤代双环化合物由式（I）表示： 其中 X1 和 X2 最好都是氟原子。该组合物可用于治疗便秘，不会产生胃痛等副作用。
• CATHARTIC COMPOSITION
  申请人：Sucampo AG

  公开号：EP1315485B1

  公开（公告）日：2007-11-21
• DOSAGE UNIT COMPRISING A PROSTAGLANDIN ANALOG FOR TREATING CONSTIPATION
  申请人：Sucampo AG

  公开号：EP1443938B1

  公开（公告）日：2011-08-31
• [EN] PHARMACEUTICAL COMBINATION OF OPIOID AND PROSTAGLANDIN COMPOUND<br/>[FR] COMBINAISON PHARMACEUTIQUE D'UN OPIOÏDE ET D'UN COMPOSÉS DE PROSTAGLANDINE
  申请人：SUCAMPO AG

  公开号：WO2009005171A1

  公开（公告）日：2009-01-08

  Provided is a pharmaceutical combination of an opioid and a prostaglandin compound of formula (I):. The combination of the invention is useful for the indications for opioid use such as pain from various etiologies.
• [EN] PHARMACEUTICAL COMBINATION OF NSAID AND PROSTAGLANDIN COMPOUND<br/>[FR] COMBINAISON PHARMACEUTIQUE D'UN AINS ET D'UN COMPOSÉ DE PROSTAGLANDINE
  申请人：SUCAMPO AG

  公开号：WO2009005172A1

  公开（公告）日：2009-01-08

  Provided is a pharmaceutical combination of a NSAID and a prostaglandin compound of formula (I). The combination of the invention is useful for the indications for NSAID use such as pain, Alzheimer disease and cancer.