2-(3-Oxo-oct-7-enyl)-cyclopentanone | 113538-21-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(3-Oxo-oct-7-enyl)-cyclopentanone
• 英文别名: 2-(3-oxooct-7-enyl)cyclopentan-1-one
• CAS: 113538-21-9
• 化学式: C₁₃H₂₀O₂
• 分子量: 208.301
• InChiKey: OAEYFLVXYOHBFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.06
• 重原子数：
  15.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  34.14
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  Allyl 2-oxo-1-(3-oxo-7-octenyl)cyclopentanecarboxylate 生成 2-(3-Oxo-oct-7-enyl)-cyclopentanone
  参考文献：
  名称：

  MINAMI, ICHIRO;NISARI, MOHAMMAD;YUHARA, MASAMI;SHIMIZU, ISAO;TSUJI, JIRO, SYNTHESIS,(1987) N 11, 992-998

  摘要：

  DOI：

文献信息

• New Methods for the Syntheses of α,β-Unsaturated Ketones, Aldehydes, and Nitriles by the Palladium-Catalyzed Reactions of Allyl β-Oxo Esters, Allyl 1-Alkenyl Carbonates, and Allyl α-Cyano Esters
  作者：Ichiro Minami、Mohammad Nisar、Masami Yuhara、Isao Shimizu、Jiro Tsuji

  DOI：10.1055/s-1987-28145

  日期：——

  Allyl β-oxo esters, allyl 1-alkenyl carbonates, and allyl α-cyano esters are converted into α,β-unsaturated ketones, aldehydes, and nitriles by palladium-catalyzed intramolecular decarboxylation-dehydrogenation. Palladium-phosphine complexes such as Pd(OAc)2-PPh3, Pd(OAc)2-dppe, or Pd2(dba)3 - CHCl3-PPh3 are effective catalysts. Yields depend on solvents and on the mole ratio of palladium to phosphine. The optimum Pd/P ratio for each substrate was determined Use of nitriles as solvents is essential for the dehydrogenation.

  烯丙基β-氧代酯、烯丙基1-烯基碳酸酯和烯丙基α-氰基酯通过钯催化的分子内脱羧脱氢反应转化为α,β-不饱和酮、醛和腈。钯-膦配合物如Pd(OAc)2-PPh3、Pd(OAc)2-dppe或Pd2(dba)3-CHCl3-PPh3是有效的催化剂。产率取决于溶剂和钯与膦的摩尔比。每个底物的最佳Pd/P比被确定。使用腈作为溶剂对脱氢是至关重要的。