2'-deoxyguanosine monohydrate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2'-deoxyguanosine monohydrate
• 英文别名: 2'-deoxyguanosine hydrate；guanosine hydrate；GUO*H2O；2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one;hydrate
• 化学式: C₁₀H₁₃N₅O₄*H₂O
• 分子量: 285.26
• InChiKey: LZSCQUCOIRGCEJ-FPKZOZHISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.48
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  136
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2'-deoxyguanosine monohydrate 在 四丁基氢氧化铵 、 sodium cyanoborohydride 作用下， 以 甲醇 、 水 为溶剂， 反应 24.0h， 生成 3-(2'-deoxy-β-D-erythro-pentofuranosyl)-5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one
  参考文献：
  名称：

  区域异构合成和特征的α-羟基-1，N（2）-丙氧基鸟苷。

  摘要：

  丙烯醛是一种已知的诱变剂，在生理条件下与2'-脱氧鸟苷和天然DNA进行体外反应，生成5,6,7,8-四氢嘧啶[1,2-a]嘌呤-10（ 3H）一类，在6或8位具有羟基（在提及1，N（2）-（丙烷桥）时，这些位置分别称为α和γ）。 8-羟基衍生物的诱变性很低，可能是因为在双链DNA中，该残基以开链醛形式[N（2）-（3-氧丙基）-2'-脱氧鸟苷]存在（5）。我们在这一领域的研究中，我们需要大量的6-羟基异构体。本论文描述了高产率的简单方法，用于批量合成6-羟基和6-甲氧基外环加合物1和3，以及一种新的有效合成1，N（2）（）-（prop-1,3 -diyl）-2'-deoxyguanosine（4），以前用作研究1，N（2）环外加成dG的物理生物学影响的化学稳定模型。

  DOI：

  10.1021/tx015568f

文献信息

• FUNCTIONAL MOLECULE, FUNCTIONAL MOLECULE SYNTHESIZING AMIDITE AND TARGET SUBSTANCE ANALYSIS METHOD
  申请人：Fujihara Tsuyoshi

  公开号：US20130017973A1

  公开（公告）日：2013-01-17

  To provide a functional molecule including a modified nucleotide unit having a substituent introduced to a base thereof, wherein the substituent is removably introduced to the base; a functional molecule synthesizing amidite that has a substituent removably introduced to its base and that is used for the manufacture of the functional molecule; and a target substance analysis method including: preparing a random pool of functional molecules using a functional molecule synthesizing amidite; screening a functional molecule having affinity for a target substance from the random pool; amplifying the functional molecules having affinity for the target substance, wherein the method further comprises, prior to the amplification step, removing a substituent from the functional molecule having affinity for the target substance.

  提供一种包括具有引入基团的修饰核苷酸单元的功能分子，其中该基团可被可拆卸地引入到基部；一种合成酰胺基的功能分子合成物，其具有可拆卸地引入到其基部的基团，并用于制造功能分子；以及一种目标物质分析方法，包括：使用功能分子合成酰胺基准备功能分子的随机池；从随机池中筛选出与目标物质有亲和力的功能分子；扩增具有与目标物质有亲和力的功能分子，其中该方法在扩增步骤之前还包括从具有与目标物质有亲和力的功能分子中去除基团。
• Biomarkers for Carcinogenesis and Uses Thereof
  申请人：GEORGETOWN UNIVERSITY

  公开号：US20190227072A1

  公开（公告）日：2019-07-25

  Provided herein are methods of reducing the recurrence of liver cancer in a subject.

  本文提供了一种减少受试者肝癌复发的方法。
• Quantification of DNA and Protein Adducts of 1-Nitropyrene: Significantly Higher Levels of Protein than DNA Adducts in the Internal Organs of 1-Nitropyrene Exposed Rats
  作者：Wan Chan、Sum-Kok Wong、Weiwei Li

  DOI：10.1021/acs.chemrestox.8b00035

  日期：2018.8.20

  1-Nitropyrene (1NP) level is closely associated with the mutagenicity of diesel exhaust and is being used as the marker molecule for diesel exhaust. Thus, quantitation of the exposure to 1NP may provide an efficient method for biomonitoring human exposure to diesel exhaust and risk assessment. Using ultra-performance liquid chromatography coupled with fluorescence or tandem mass spectrometric detection methods, we quantitated and compared in this study the DNA and protein adducts of 1NP in internal organs of 1NP-exposed rats. While previous studies using radioactivity-based detection methods were descriptive in nature and focused on the mutation-associated genetic materials, the results of our quantitative analysis showed, for the first time, a significantly higher concentration of the protein adduct than the DNA adduct in the tissue samples. The data also revealed higher in vivo stability of the protein adduct than that of the DNA adduct. Our results provide solid evidence that demonstrates that the protein adduct might be a more-sensitive dosimeter for 1-NP and, thus, diesel-exhaust exposure.

  1-硝基苯芘（1NP）水平与柴油废气的致突变性密切相关，被用作柴油废气的标记分子。因此，定量检测 1NP 的暴露量可为人类暴露于柴油废气的生物监测和风险评估提供一种有效的方法。在本研究中，我们使用超高效液相色谱法结合荧光或串联质谱检测方法，对暴露于 1NP 的大鼠内脏中的 1NP DNA 和蛋白质加合物进行了定量和比较。以往使用基于放射性的检测方法进行的研究都是描述性的，重点关注与突变相关的遗传物质，而我们的定量分析结果首次显示，组织样本中蛋白质加合物的浓度明显高于 DNA 加合物。数据还显示，蛋白质加合物在体内的稳定性高于 DNA 加合物。我们的研究结果提供了确凿的证据，证明蛋白质加合物可能是一种对 1-NP 更敏感的剂量计，因此也是一种柴油废气暴露剂量计。
• Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
  申请人：Pro-Neuron, Inc.

  公开号：US20040235782A1

  公开（公告）日：2004-11-25

  The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematopoiesis, and treating or preventing inflammatory diseases and bacterial infections by administering a compound or composition of the present invention to an animal.

  本发明涉及某些氧杂嘌呤核苷、这些氧杂嘌呤核苷的同系物和酰基衍生物，以及至少含有这些化合物之一的组合物。本发明还涉及通过向动物施用本发明的化合物或组合物来治疗或预防造血障碍和调节造血以及治疗或预防炎症性疾病和细菌感染的方法。
• Oxypurine nucleosides and their congeners, and acyl derivatives thereof,
  申请人：Pro-Neuron, Inc.

  公开号：US06054441A1

  公开（公告）日：2000-04-25

  The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematopoiesis, and treating or preventing inflammatory diseases and bacterial infections by administering a compound or composition of the present invention to an animal.

  本发明涉及某些氧杂嘌呤核苷、这些氧杂嘌呤核苷的同系物和酰基衍生物，以及至少含有这些化合物之一的组合物。本发明还涉及通过向动物施用本发明的化合物或组合物来治疗或预防造血障碍和调节造血以及治疗或预防炎症性疾病和细菌感染的方法。