2-chloro-4,6-di(4'-methoxyphenoxy)-1,3,5-triazine | 60717-15-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-chloro-4,6-di(4'-methoxyphenoxy)-1,3,5-triazine
• 英文别名: 2-chloro-4,6-bis(4'-methoxyphenoxy)-1,3,5-triazine；2-Chlor-4,6-bis-(4-methoxy-phenoxy)-s-triazin；chloro-bis-(4-methoxy-phenoxy)-[1,3,5]triazine；Chlor-bis-(4-methoxy-phenoxy)-[1,3,5]triazin；2,4-bis(4-methoxyphenoxy)-6-chloro-s-triazine；2-Chloro-4,6-bis(4-methoxyphenoxy)-1,3,5-triazine
• CAS: 60717-15-9
• 化学式: C₁₇H₁₄ClN₃O₄
• 分子量: 359.769
• InChiKey: CAHLHZJFJMXPBJ-UHFFFAOYSA-N

物化性质

• 熔点：
  123-124 °C(Solvent: Ligroine ; Benzene)
• 沸点：
  549.4±60.0 °C(Predicted)
• 密度：
  1.331±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  75.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  环己基乙炔 、 2-chloro-4,6-di(4'-methoxyphenoxy)-1,3,5-triazine 在 palladium on activated charcoal copper(l) iodide 、 N,N-二异丙基乙胺 、 三苯基膦 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以90%的产率得到2-[2'-(1''-hydroxycyclohex-1''-yl)-ethynyl]-4,6-di-(4''-methoxyphenoxy)-1,3,5-triazine
  参考文献：
  名称：

  Palladium on carbon catalyzed cross-coupling between alk-1-ynes and 2-chloro-4,6-dialkoxy-1,3,5-triazines

  摘要：

  2-(Alk-1'-ynyl)-4,6-dialkoxy-1,3,5-triazines have been synthesized in satisfactory yields by (Pd/C)/PPh3/CuI catalyzed cross-coupling between alk-1-ynes and 2-chloro-4,6-dialkoxy-1,3,5-triazines carried out in the presence of diisopropylethylamine or K2CO3/18-crown-6. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)01230-3
• 作为产物：
  描述：

  三聚氯氰 、 4-甲氧基苯酚 在 18-冠醚-6 、 potassium carbonate 作用下， 以 苯 为溶剂， 反应 22.0h， 以96%的产率得到2-chloro-4,6-di(4'-methoxyphenoxy)-1,3,5-triazine
  参考文献：
  名称：

  Selective Mono- or Dialkoxylation of 2,4,6-Trichloro-1,3,5-triazine in Solid-Liquid Phase Transfer Conditions

  摘要：

  In solid-liquid phase transfer conditions, both the primary and the secondary alcohols react cleanly with 2,4, 6-trichloro-1,3,5-triazine to give the corresponding mono or dialkoxy derivatives depending on the reagent molar ratio.

  DOI：

  10.1080/00397919408010229

文献信息

• Aryloxytriazine-capped polyphenylene ethers and method for their preparation
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0386544A2

  公开（公告）日：1990-09-12

  Aryloxytriazine-capped polyphenylene ethers are prepared by reaction of a polyphenylene ether with an aryl­oxychlorotriazine such as diphenyl chlorocyanurate. The products undergo reaction with amine-terminated polymers such as polyamides, to form compositions which have excellent properties and which find utility as molding compositions and as compatibilizers for blends of similar polymers.

  芳氧基三嗪封端聚苯醚是通过聚苯醚与芳氧基氯三嗪（如二苯基氯氰脲酸酯）反应制备的。产品与胺封端聚合物（如聚酰胺）发生反应，形成具有优异性能的组合物，可用作成型组合物和类似聚合物混合物的相容剂。
• Polyphenylene ether-polyamide compositions from aryloxytriazine-capped polyphenylene ethers
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0386545A2

  公开（公告）日：1990-09-12

  Aryloxytriazine-capped polyphenylene ethers are prepared by reaction of a polyphenylene ether with an aryl­oxychlorotriazine such as diphenyl chlorocyanurate. The products undergo reaction with amine-terminated polymers such as polyamides, to form compositions which have excellenr properties and which find utility as molding compositions and as compatibilizers for blends of similar polymers.

  芳氧基三嗪封端聚苯醚是通过聚苯醚与芳氧基氯三嗪（如二苯基氯氰脲酸酯）反应制备的。产品与胺封端聚合物（如聚酰胺）发生反应，形成具有优异性能的组合物，可用作成型组合物和类似聚合物混合物的相容剂。
• Polyphenylene ether resins
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0550209A2

  公开（公告）日：1993-07-07

  A method for the preparation of polyphenylene ether resins having increased hydroxyl content and, particularly, increased non-Mannich hydroxyl content comprises reaction of biphenol with polyphenylene ether resin. Polyphenylene ether resins obtained by such method, as well as the reaction products between such polyphenylene ether resins and hydroxyl-reactive substituents, such as epoxy chlorotriazines, and compositions containing such reaction products and thermoplastic resins not normally compatible with polyphenylene ether resin, such as polyester resin are also disclosed.

  制备羟基含量增加，特别是非曼尼希羟基含量增加的聚苯醚树脂的方法包括联苯酚与聚苯醚树脂反应。此外，还公开了通过这种方法获得的聚苯醚树脂，以及这种聚苯醚树脂与羟基反应性取代基（如环氧氯三嗪）之间的反应产物，以及含有这种反应产物和通常与聚苯醚树脂不相容的热塑性树脂（如聚酯树脂）的组合物。
• Palladium on carbon catalyzed cross-coupling between alk-1-ynes and 2-chloro-4,6-dialkoxy-1,3,5-triazines
  作者：Simona Samaritani、Rita Menicagli

  DOI：10.1016/s0040-4020(01)01230-3

  日期：2002.2

  2-(Alk-1'-ynyl)-4,6-dialkoxy-1,3,5-triazines have been synthesized in satisfactory yields by (Pd/C)/PPh3/CuI catalyzed cross-coupling between alk-1-ynes and 2-chloro-4,6-dialkoxy-1,3,5-triazines carried out in the presence of diisopropylethylamine or K2CO3/18-crown-6. (C) 2002 Elsevier Science Ltd. All rights reserved.
• In Vitro Cytotoxic Activities of 2-Alkyl-4,6-diheteroalkyl-1,3,5-triazines:  New Molecules in Anticancer Research
  作者：Rita Menicagli、Simona Samaritani、Giovanni Signore、Francesca Vaglini、Lisa Dalla Via

  DOI：10.1021/jm0495374

  日期：2004.9.1

  The cytotoxic activities of new 2-alkyl-4,6-dihetero-(N,O)alkyl-1,3,5-triazines toward selected tumor cell lines have been evaluated, and for the first time, the potential of 2-alkyl-4,6-dialkoxy-1,3,5-triazines has been shown.