N-tert-butyl-N'-(4-methyl-1,2,3-thiadiazole)-5-formylhydrazine | 1202366-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-tert-butyl-N'-(4-methyl-1,2,3-thiadiazole)-5-formylhydrazine
• 英文别名: N'-tert-butyl-4-methylthiadiazole-5-carbohydrazide
• CAS: 1202366-00-4
• 化学式: C₈H₁₄N₄OS
• 分子量: 214.291
• InChiKey: CFUQNCAWHCFOKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-tert-butyl-N'-(4-methyl-1,2,3-thiadiazole)-5-formylhydrazine 、 甲氧基苯甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以44%的产率得到N'-tert-butyl-N'-(2-methoxybenzoyl)-4-methylthiadiazole-5-carbohydrazide
  参考文献：
  名称：

  Synthesis and Insecticidal Activity of N-tert-Butyl-N,N′-diacylhydrazines Containing 1,2,3-Thiadiazoles

  摘要：

  N-tert-Butyl-N,N'-diacylhydrazines are nonsteroidal ecdysone agonists used as environmental benign pest regulators. In this paper, two series of new N-tert-butyl-N,N'-diacylhydrazine derivatives containing 1,2,3-thiadiazole were designed and synthesized. All structures of the synthesized compounds were confirmed by proton nuclear magnetic resonance (H-1 NMR), infrared spectroscopy (IR), and high-resolution mass spectrometry (HRMS). Bioasssay results indicated that most of the synthesized compounds possessed good insecticidal activities against Plutella xylostella L. and Culex pipiens pallens as compared with the positive control, tebufenozide. The results of this study indicated that 1,2,3-thiadiazoles, as an important active substructure, could improve or maintain the activity of the dicylhydrazines and favor novel pesticide development.

  DOI：

  10.1021/jf104004q
• 作为产物：
  描述：

  4-甲基-1，2，3-噻二唑-5-羰酰氯 、 叔丁基肼盐酸盐 在 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 以80.1%的产率得到N-tert-butyl-N'-(4-methyl-1,2,3-thiadiazole)-5-formylhydrazine
  参考文献：
  名称：

  Synthesis and Insecticidal Activity of N-tert-Butyl-N,N′-diacylhydrazines Containing 1,2,3-Thiadiazoles

  摘要：

  N-tert-Butyl-N,N'-diacylhydrazines are nonsteroidal ecdysone agonists used as environmental benign pest regulators. In this paper, two series of new N-tert-butyl-N,N'-diacylhydrazine derivatives containing 1,2,3-thiadiazole were designed and synthesized. All structures of the synthesized compounds were confirmed by proton nuclear magnetic resonance (H-1 NMR), infrared spectroscopy (IR), and high-resolution mass spectrometry (HRMS). Bioasssay results indicated that most of the synthesized compounds possessed good insecticidal activities against Plutella xylostella L. and Culex pipiens pallens as compared with the positive control, tebufenozide. The results of this study indicated that 1,2,3-thiadiazoles, as an important active substructure, could improve or maintain the activity of the dicylhydrazines and favor novel pesticide development.

  DOI：

  10.1021/jf104004q