2-benzyl-4-phenyl-1(3)H-imidazole | 1724-62-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-benzyl-4-phenyl-1(3)H-imidazole
• 英文别名: 2-Benzyl-4-phenyl-1(3)H-imidazol；Phenylbenzylimidazole；2-benzyl-5-phenyl-1H-imidazole
• CAS: 1724-62-5
• 化学式: C₁₆H₁₄N₂
• 分子量: 234.301
• InChiKey: JUEBSZPWUQYFOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-azido-1-phenylethan-1-one 在 二苯醚 、 异戊醇 、 sodium 作用下， 生成 2-benzyl-4-phenyl-1(3)H-imidazole
  参考文献：
  名称：

  Azidocarbonyl Compounds. I. A New Synthesis for Certain Substituted Imidazoles from Phenacyl Azides¹

  摘要：

  DOI：

  10.1021/ja01138a011

文献信息

• Compounds and methods for the inhibition of compounds cruzi
  申请人：Hamilton D Andrew

  公开号：US20060167269A1

  公开（公告）日：2006-07-27

  The present invention relates to compounds according to the formula (I): Where R A is a C 1 -C 10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group according to the formula (II): R B is a C 1 -C 10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group of the formula (III): R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are each independently selected from H, C 1 -C 10 (preferably a C 1 -C 4 ) alkyl or alkenyl group, CF 3 , F, Cl, Br, I, CN, NO 2 , NH 2 , NHR, NRR, COR (acyl group), OR (hydroxyl or ether group), CO 2 R (carboxylic acid or ester group), or COSR (thioester group) where R is H or a C 1 -C 10 (preferably a C 1 -C 4 ) alkyl or alkenyl group, an unsubstituted or substituted aryl (preferably, phenyl) or heterocycle group, or a (IV) group, where R 3 is H, a C 1 -C 10 (preferably a C 1 -C 4 ) alkyl, alkenyl, ether or a thioether group; and R 11 and R 12 are independently selected from H or a C 1 -C 3 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof and methods for treating infections caused by protozoal, fungal and/or bacterial agents such as Trypanosoma cruzi, Mycobacterium spp., Leishmania spp., Cryptococcus spp., Aspergillus spp., Histoplasma spp., Candida spp., especially Candida albicans, Pneumocystis carinii, Trichophyton spp., Microsporum spp., Malassezia spp., Rhizopus spp., Pseudallescheria spp., Blastomyces dermatitidis and Coccidiodes spp., among others.

  本发明涉及式(I)的化合物：其中RA是C1-C10取代或未取代的线性、支链或环烷基或烯基或式(II)的苯基：RB是C1-C10取代或未取代的线性、支链或环烷基或烯基或式(III)的苯基：R1、R2、R3、R4、R5、R6、R7、R8、R9和R10各自独立地选自H、C1-C10(优选为C1-C4)烷基或烯基、CF3、F、Cl、Br、I、CN、NO2、NH2、NHR、NRR、COR（酰基）、OR（羟基或醚基）、CO2R（羧酸或酯基）或COSR（硫酯基），其中R是H或C1-C10(优选为C1-C4)烷基或烯基、未取代或取代的芳基（优选为苯基）或杂环基，或式(IV)的基团，其中R3是H、C1-C10(优选为C1-C4)烷基、烯基、醚或硫醚基；R11和R12各自独立地选自H或C1-C3烷基或烯基，或其药学上可接受的盐，以及用于治疗由原虫、真菌和/或细菌引起的感染的方法，例如TrypanOSoma cruzi，Mycobacterium spp.，Leishmania spp.，Cryptococcus spp.，Aspergillus spp.，Histoplasma spp.，Candida spp.，特别是Candida albicans，Pneumocystis carinii，Trichophyton spp.，MicrOSporum spp.，Malassezia spp.，Rhizopus spp.，Pseudallescheria spp.，Blastomyces dermatitidis和Coccidioides spp.等。
• Novel 2,2'-BI-1H-imidazoles
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0229922A2

  公开（公告）日：1987-07-29

  This invention relates to novel derivatives of 2,2'-bi-1H-imidazoles, to the processes and intermediates used in their preparation, to their ability to exert the pharmacologic effects of lowering high blood pressure and of increasing heart contractile force and to their use as chemotherapeutic agents useful in treating cardiac insufficiency and hypertension.

  本发明涉及 2,2'-bi-1H-咪唑的新型衍生物、制备过程和中间体、降低高血压和增加心脏收缩力的药理作用，以及用作治疗心功能不全和高血压的化疗药物。
• Surface treating composition for copper and copper alloy and utilization thereof
  申请人：SHIKOKU CHEMICALS CORPORATION

  公开号：US10398028B2

  公开（公告）日：2019-08-27

  A surface treating composition for copper or a copper alloy comprising an imidazole compound and means for using the composition in the soldering of electronic parts to printed wiring boards are disclosed.

  本发明公开了一种包含咪唑化合物的铜或铜合金表面处理组合物，以及在将电子零件焊接到印刷线路板时使用该组合物的方法。
• Verfahren zur Bestimmung realistischer UV-Schutzfaktoren oder Breitspektrumindizes
  申请人：Coty B.V.

  公开号：EP1324017B1

  公开（公告）日：2004-10-27
• STABLE SUNSCREEN COMPOSITIONS CONTAINING ZINC OXIDE
  申请人：AMCOL INTERNATIONAL CORPORATION

  公开号：EP1904186B1

  公开（公告）日：2009-11-04