octyl 1-thio-β-D-xylopyranoside | 72669-51-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: octyl 1-thio-β-D-xylopyranoside
• 英文别名: (2S,3R,4S,5R)-2-octylsulfanyloxane-3,4,5-triol
• CAS: 72669-51-3
• 化学式: C₁₃H₂₆O₄S
• 分子量: 278.413
• InChiKey: XGZHMPCHKOELCY-XQHKEYJVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  95.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• NEPHROTROPIC DRUGS
  申请人：Drug Delivery System Institute, Ltd.

  公开号：EP0953357A1

  公开（公告）日：1999-11-03

  Disclosed are a drug having renal selectivity and a drug carrier for specifically transporting a drug supported thereon to a kidney. A segment structure specifically recognizable in the kidney is utilized. More specifically, since a segment structure represented by formula (I) is kidney-oriented, introduction of a drug into a molecule having the segment structure can provide a renal targeting drug. A compound, which has the segment structure and can support a drug thereon, can be utilized as a drug carrier which can specifically transport a drug supported thereon to the kidney.         A-U-V-     (I) wherein A represents glycosyl, such as glucosyl, mannosyl, or 2-deoxy-glucosyl; U represents O, S, or NH; and V represents an aromatic hydrocarbon or a straight-chain or branched C1-18 aliphatic hydrocarbon.

  本发明涉及一种具有肾脏选择性的药物和一种药物载体，用于将支持在其上的药物专门运输到肾脏。利用在肾脏中特别可识别的片段结构。更具体地说，由式（I）表示的片段结构是以肾脏为导向的，将药物引入具有该片段结构的分子中可以提供肾脏靶向药物。具有该片段结构并能支持药物的化合物可用作药物载体，可将支持在其上的药物专门运输到肾脏。其中，A代表糖基，如葡萄糖基、甘露糖基或2-脱氧葡萄糖基；U代表O、S或NH；V代表芳香族碳氢化合物或直链或支链C1-18脂肪族碳氢化合物。
• D-Xylopyranoside series compounds and therapeutical compositions containing same
  申请人：Seikagaku Kogyo Co. Ltd.

  公开号：EP0053827A2

  公开（公告）日：1982-06-16

  Disclosed are D-xylopyranoside series compounds represented by the following general formula: in which R' represents a benzyl group, (X, Y and p are as defined in the specification), -S-R2 (R2 is as defined in the specification), or an alkyl group having from 6 to 25 carbon atoms. In form of therapeutical compositions the compounds are effective against various deseases, including those cansed by lipid deposition on to the walls of blood vessels and cancer.

  本发明公开了由以下通式代表的 D-酰基吡喃糖苷系列化合物：其中 R'代表苄基（X、Y 和 p 如说明书中所定义）、-S-R2（R2 如说明书中所定义）或具有 6 至 25 个碳原子的烷基。 以治疗组合物的形式，这些化合物可有效防治各种疾病，包括因脂质沉积在血管壁上而引起的疾病和癌症。
• US4454123A
  申请人：——

  公开号：US4454123A

  公开（公告）日：1984-06-12