| 1202796-99-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1202796-99-3
• 化学式: C₂F₃O₂*C₂HF₃O₂*C₁₉H₂₁N₄O
• 分子量: 548.442
• InChiKey: NJWGZGCGENZDDE-UHFFFAOYSA-M

反应信息

• 作为反应物：
  描述：

  、 乙酸酐 以 乙腈 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Solid-Phase Synthesis and Chemical Properties of 2-(2-Amino/hydroxyethyl)-1-aryl-3,4-dihydropyrazino[1, 2-b]indazol-2-iums

  摘要：

  Amino alcohols, diamines, benzenesulfonyl chlorides, and bromoketones were used to prepare polymer-supported 2-(2-(2-(amino/hydroxyl)ethylamino)ethyl)-3-benzoyl-2H-indazoles. Acid-mediated release yielded 2-((amino/hydroxyl)ethyl)-1-aryl-3,4-dihydropyrazino[1,2-b]indazole-2-iums. In neutral pH, iminiums spontaneously cyclized to complex fused heterocycles 3,6,9,10-tetraazatetracyclo[7.7.0.0(2,6).0(11,16)]hexadeca-11,13,15-trienes, 3-oxa-6,9,10-triazatetracyclo[7.7.0.0(2,6).0(11,16)]hexadeca-11,13,15-trienes, and 3,7,10,11-tetraazatetracyclo[8.7.0.0(2,7).0(12,17)]heptadeca-12,14,16-trienes. Transformations were carried out under mild conditions and tolerated diverse substitution patterns.

  DOI：

  10.1021/cc9001422
• 作为产物：
  描述：

  三氟乙酸 、 2,6-Dichloro-4-[13-(trifluoromethyl)-3,6,9,10-tetrazatetracyclo[7.7.0.02,6.011,16]hexadeca-1(16),10,12,14-tetraen-2-yl]aniline 以 二氯甲烷 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Solid-Phase Synthesis and Chemical Properties of 2-(2-Amino/hydroxyethyl)-1-aryl-3,4-dihydropyrazino[1, 2-b]indazol-2-iums

  摘要：

  Amino alcohols, diamines, benzenesulfonyl chlorides, and bromoketones were used to prepare polymer-supported 2-(2-(2-(amino/hydroxyl)ethylamino)ethyl)-3-benzoyl-2H-indazoles. Acid-mediated release yielded 2-((amino/hydroxyl)ethyl)-1-aryl-3,4-dihydropyrazino[1,2-b]indazole-2-iums. In neutral pH, iminiums spontaneously cyclized to complex fused heterocycles 3,6,9,10-tetraazatetracyclo[7.7.0.0(2,6).0(11,16)]hexadeca-11,13,15-trienes, 3-oxa-6,9,10-triazatetracyclo[7.7.0.0(2,6).0(11,16)]hexadeca-11,13,15-trienes, and 3,7,10,11-tetraazatetracyclo[8.7.0.0(2,7).0(12,17)]heptadeca-12,14,16-trienes. Transformations were carried out under mild conditions and tolerated diverse substitution patterns.

  DOI：

  10.1021/cc9001422