Acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-[2-acetoxymethyl-2-acryloylamino-3-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-propoxy]-tetrahydro-pyran-4-yl ester | 151753-75-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-[2-acetoxymethyl-2-acryloylamino-3-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-propoxy]-tetrahydro-pyran-4-yl ester
• CAS: 151753-75-2
• 化学式: C₃₇H₅₁NO₂₃
• 分子量: 877.805
• InChiKey: YDPVUFJBMASQKU-OVTMGIBXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.21
• 重原子数：
  61.0
• 可旋转键数：
  20.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  302.72
• 氢给体数：
  1.0
• 氢受体数：
  23.0

反应信息

• 作为反应物：
  描述：

  Acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-[2-acetoxymethyl-2-acryloylamino-3-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-propoxy]-tetrahydro-pyran-4-yl ester 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以100%的产率得到N-[1-Hydroxymethyl-2-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxymethyl)-ethyl]-acrylamide
  参考文献：
  名称：

  Synthèse de glycolipides polymérisables Dérivés du Tris(hydroxyméthyl)aminométhane: Préparation de micelles polymérisées.

  摘要：

  We have synthesized a series of new polymerizable glycolipids derived from Tris(hydroxymethyl) aminomethane (TRIS). Galactosylation of TRIS was performed in good yield by means of ultrasounds. Polymerization of 11-N-acrylamido-N-Tris(beta-D-galactopyranosyl oxymethyl)methyl undecanamide in aqueous solution by UV irradiation, led to polymerized micellar structures (A).

  DOI：

  10.1016/s0040-4039(00)60523-3
• 作为产物：
  描述：

  5-Acrylamido-5-acetoxymethyl-2,2-dimethylcyclo-1,3-dioxahexane 在 氰化汞 、 溶剂黄146 作用下， 以 乙腈 为溶剂， 生成 Acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-[2-acetoxymethyl-2-acryloylamino-3-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-propoxy]-tetrahydro-pyran-4-yl ester
  参考文献：
  名称：

  Synthèse de glycolipides polymérisables Dérivés du Tris(hydroxyméthyl)aminométhane: Préparation de micelles polymérisées.

  摘要：

  We have synthesized a series of new polymerizable glycolipids derived from Tris(hydroxymethyl) aminomethane (TRIS). Galactosylation of TRIS was performed in good yield by means of ultrasounds. Polymerization of 11-N-acrylamido-N-Tris(beta-D-galactopyranosyl oxymethyl)methyl undecanamide in aqueous solution by UV irradiation, led to polymerized micellar structures (A).

  DOI：

  10.1016/s0040-4039(00)60523-3