4-Iodo-3-methoxy-2-methylpyridine | 1227515-23-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Iodo-3-methoxy-2-methylpyridine
• CAS: 1227515-23-2
• 化学式: C₇H₈INO
• 分子量: 249.05
• InChiKey: GRXJRWLTZRYALV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HALO AND TRIFLUOROMETHYL SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20160068514A1

  公开（公告）日：2016-03-10

  The present invention is directed to halo and trifluoromethyl substituted compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及卤代和三氟甲基取代化合物，其为促进素受体拮抗剂。本发明还涉及所述化合物在潜在的神经系统和精神疾病的治疗或预防中的用途，其中促进素受体参与其中。本发明还涉及包含这些化合物的制药组合物。本发明还涉及这些制药组合物在预防或治疗促进素受体参与的这些疾病中的用途。
• [EN] SULFOXIMINE COMPOUND AND USE THEREOF<br/>[FR] COMPOSÉ SULFOXIMINE ET SON UTILISATION<br/>[ZH] 亚磺酰亚胺类化合物及其应用
  申请人：MEDSHINE DISCOVERY INC

  公开号：WO2022268119A1

  公开（公告）日：2022-12-29

  涉及亚磺酰亚胺类化合物及其应用，具体公开了下式化合物或其药学上可接受的盐。