2-(1-Hydroxy-propyl)-cyclohexanol | 98955-26-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(1-Hydroxy-propyl)-cyclohexanol
• 英文别名: 2-Hydroxy-1-(1-hydroxy-propyl)-cyclohexan；2-(1-hydroxypropyl)cyclohexan-1-ol
• CAS: 98955-26-1
• 化学式: C₉H₁₈O₂
• 分子量: 158.241
• InChiKey: IRORBXUOUURXRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(1-hydroxypropyl)cyclohex-2-en-1-one 在 sodium tetrahydroborate 、 cerium(III) chloride hexahydrate 作用下， 以 甲醇 为溶剂， 以64 %的产率得到2-(1-hydroxypropyl)cyclohex-2-en-1-ol
  参考文献：
  名称：

  Al(OiPr)3 作为增强 Meerwein−Ponndorf−Verley (MPV) 还原 Morita-Baylis-Hillman (MBH) 环醇的有效催化剂

  摘要：

  使用 NaBH 进行羰基还原通常是有机合成和制药工业中常用的高产率和高选择性过程。然而，该反应是放热的，并且NaBH溶液的稳定性有限，导致反应时间较长。在这项工作中，报道了在 MeOH 中用 CeCl/NaBH 有效还原 MBH 醇。此外，在该方法中，使用异丙醇铝和异丁醇作为转移过程中的质子源。该方法表现出令人印象深刻的选择性和高产率，从而形成所需的双齿烯丙醇。

  DOI：

  10.1016/j.molstruc.2024.138950

文献信息

• New bicyclic dioxanes, their preparation and their use as organoleptic compounds
  申请人：V.Mane Fils

  公开号：EP2287159A1

  公开（公告）日：2011-02-23

  The present invention relates to novel 1,3-dioxane derivatives of formula (I) wherein each of R1 and R2 is a hydrogen atom, R3 and R4 are independently a hydrogen atom, a linear or branched C1-C6 alkyl group, or a linear or branched C2-C6 alkenyl group, and R5 is a linear or branched C1-C6 alkyl group, a linear or branched C2-C6 alkenyl group or a (CH2)0-2 - aryl group, and R6 and R7 are independently a hydrogen atom, a linear or branched C1-C6 alkyl group, a linear or branched C2-C6 alkenyl group or a (CH2)0-2 - aryl group, or R6 and R7 together with the carbon atom to which they are attached form a C5-C6 cycloalkyl group or a C5-C6 cycloalkenyl group, substituted or not; their preparation and their use as organoleptic compounds.

  本发明涉及新颖的1,3-二噁烷衍生物，其化学式为（I），其中R1和R2中的每个都是氢原子，R3和R4分别是氢原子、直链或支链的C1-C6烷基基团，或直链或支链的C2-C6烯基基团，R5是直链或支链的C1-C6烷基基团、直链或支链的C2-C6烯基基团或（CH2）0-2芳基基团，R6和R7分别是氢原子、直链或支链的C1-C6烷基基团、直链或支链的C2-C6烯基基团或（ ）0-2芳基基团，或者R6和R7与它们连接的碳原子一起形成取代或非取代的C5-C6环烷基基团或C5-C6环烯基基团；它们的制备及其用作感官化合物。
• [EN] NEW BICYCLIC DIOXANES, THEIR PREPARATION AND THEIR USE AS FRAGRANT COMPOUNDS<br/>[FR] NOUVEAUX DIOXANES BICYCLIQUES, LEUR PRÉPARATION ET LEUR UTILISATION EN TANT QUE COMPOSÉS DE PARFUM
  申请人：MANE FILS V

  公开号：WO2011013077A1

  公开（公告）日：2011-02-03

  The invention is directed to the use of compounds of formula (I), as fragrant agents. In this formula: - R3 and R4 are independently a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group, R5 is a C1-C6 alkyl group, a C2-C6 alkenyl group or a (CH2)0-2-aryl group, R6 is a C1 -C6 alkyl group, a C2-C6 alkenyl group, a (CH2)0-2-aryl group or a C5- C6 cycloalkyl or cycloalkenyl group, and R7 is a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group; or R3, R4 and R5 are as above defined, and R6 and R7 together with the carbon atom to which they are attached form a C5-C6 cycloalkyl or cycloalkenyl group.

  该发明涉及使用式（I）的化合物作为香料剂。在这个式子中：- R3和R4独立地是氢原子，C1-C6烷基或C2-C6烯基，R5是C1-C6烷基，C2-C6烯基或（CH2）0-2-芳基，R6是C1-C6烷基，C2-C6烯基，（ ）0-2-芳基或C5-C6环烷基或环烯基，R7是氢原子，C1-C6烷基或C2-C6烯基；或者R3，R4和R5如上定义，R6和R7与它们连接的碳原子一起形成C5-C6环烷基或环烯基。
• New Bicyclic Dioxanes, Their Preparation and Their Use as Fragrant Compounds
  申请人：Chanot Jean-Jacques

  公开号：US20120165557A1

  公开（公告）日：2012-06-28

  The invention is directed to the use of compounds of formula (I), as fragrant agents. In this formula: —R 3 and R 4 are independently a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group, R 5 is a C1-C6 alkyl group, a C2-C6 alkenyl group or a (CH2) 0-2 -aryl group, R 6 is a C1-C6 alkyl group, a C2-C6 alkenyl group, a (CH2) 0-2 -aryl group or a C5-C6 cycloalkyl or cycloalkenyl group, and R 7 is a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group; or R 3 , R 4 and R 5 are as above defined, and R 6 and R 7 together with the carbon atom to which they are attached form a C5-C6 cycloalkyl or cycloalkenyl group.

  本发明涉及使用式（I）化合物作为香味剂。在此式中：—R3和R4独立地是氢原子、C1-C6烷基或C2-C6烯基基团，R5是C1-C6烷基、C2-C6烯基或（CH2）0-2芳基基团，R6是C1-C6烷基、C2-C6烯基、（ ）0-2芳基基团或C5-C6环烷基或环烯基基团，而R7是氢原子、C1-C6烷基或C2-C6烯基基团；或者R3、R4和R5如上所定义，而R6和R7连同它们所连接的碳原子形成C5-C6环烷基或环烯基基团。
• General and selective homogeneous Ru-catalyzed transfer hydrogenation, deuteration, and methylation of functional compounds using methanol
  作者：Murugan Subaramanian、Ganesan Sivakumar、Vinod G. Landge、Rohit Kumar、Kishore Natte、Rajenahally V. Jagadeesh、Ekambaram Balaraman

  DOI：10.1016/j.jcat.2023.06.035

  日期：2023.9

  pharmaceuticals such as d-Cloperastine, d-Buclizine, d-Diphendyarmine, d-Modafinil, and d-Adrafinil using CD3OD. In addition, the application of methanol as a C1 source for the preparation of N-methylated products is showcased. Finally, kinetic and mechanistic investigations for this Ru-catalyzed transfer hydrogenation and deuteration protocols have been performed.

  有机合成和能源技术中甲醇的催化增值对于基础研究和工业应用来说都是有趣且重要的。特别是，它作为氢、氘和甲基源用于选择性还原和氘化反应以及获得N-甲基化产物是非常理想的，并且可以被认为是放大转移氢化和C1化学的潜在方法。在这里，我们报道了均相 Ru-MACHO 配合物催化不同官能化化合物（如酮、醛、炔烃、烯烃、亚胺、偶氮苯和硝基化合物）的转移氢化以及N的脱氧使用甲醇作为负担得起的氢供体和溶剂的氧化物衍生物。这种基于钌的策略已被证明对于合成先进氘标记化合物的氘化过程非常方便，包括克级合成氘代药物，如d-氯哌斯汀、d-布克利嗪、d-苯地亚明、d-莫达非尼和d -Adrafinil 使用 CD 3 OD。此外，还展示了甲醇作为C1源用于制备N-甲基化产物的应用。最后，对这种钌催化的转移氢化和氘化方案进行了动力学和机理研究。
• THERMOPLASTIC RESIN COMPOSITION AND MOLDED ARTICLE COMPRISING THE SAME
  申请人：Lotte Advanced Materials Co., Ltd.

  公开号：EP3135728A1

  公开（公告）日：2017-03-01

  A thermoplastic resin composition and a molded article including the same are disclosed herein. The thermoplastic resin composition includes a base resin including a polycarbonate (PC) resin and a polyester resin, inorganic fillers, and an aromatic (meth)acrylate polymer, wherein the aromatic (meth)acrylate polymer is a copolymer of a monomer mixture including a vinyl cyanide monomer, an aromatic vinyl monomer, and an aromatic (meth)acrylate.

  本文公开了一种热塑性树脂组合物和包括该组合物的模塑制品。该热塑性树脂组合物包括基树脂（包括聚碳酸酯（PC）树脂和聚酯树脂）、无机填料和芳香族（甲基）丙烯酸酯聚合物，其中芳香族（甲基）丙烯酸酯聚合物是单体混合物的共聚物，该单体混合物包括乙烯基氰化物单体、芳香族乙烯基单体和芳香族（甲基）丙烯酸酯。