1-allyl-3-methyl-6-amino uracil | 7052-53-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-allyl-3-methyl-6-amino uracil
• 英文别名: 1-allyl-6-amino-3-methyl-1H-pyrimidine-2,4-dione；1-Allyl-6-amino-3-methyl-1H-pyrimidin-2,4-dion；1-Allyl-6-amino-3-methyluracil；6-amino-3-methyl-1-prop-2-enylpyrimidine-2,4-dione
• CAS: 7052-53-1
• 化学式: C₈H₁₁N₃O₂
• 分子量: 181.194
• InChiKey: OCSRIEOBSUDSMV-UHFFFAOYSA-N

物化性质

• 熔点：
  143-144 °C
• 沸点：
  276.7±50.0 °C(Predicted)
• 密度：
  1.211±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  1-allyl-3-methyl-6-amino uracil 在 platinum(IV) oxide 氢气 、 溶剂黄146 、 sodium nitrite 作用下， 以 甲醇 、 水 为溶剂， 生成 5,6-diamino-3-methy-1-propenylluracil
  参考文献：
  名称：

  Inhibition of separated forms of cyclic nucleotide phosphodiesterase from pig coronary arteries by 1,3-disubstituted and 1,3,8-trisubstituted xanthines

  摘要：

  A series of xanthines with varied substituents in the 1, 3, and 8 positions were prepared in an attempt to understand the structure--activity relationship for alkylxanthines as inhibitors of two different forms of cyclic nucleotide phosphodiesterase. Polar substituents on the 1 or 3 position of the xanthine reduced the potency of the xanthines to inhibit both the calmodulin-sensitive and the "cyclic AMP specific" forms of phosphodiesterase. Polar substituents on the 8 position of the xanthine, other than a carboxylic acid, increased the potency to inhibit the calmodulin-sensitive form of phosphodiesterase, if they were capable of donating electrons to the xanthine nucleus. On the other hand, any substituent in the 8 position larger than H reduced the potency of the xanthines to inhibit the cyclic AMP specific form of phosphodiesterase. Topographical maps of the active sites of the two forms of phosphodiesterase are presented in summary.

  DOI：

  10.1021/jm00140a008
• 作为产物：
  描述：

  N-(allylcarbamoyl)-2-cyanoacetamide 在 sodium hydroxide 、 乙醇 作用下， 生成 1-allyl-3-methyl-6-amino uracil
  参考文献：
  名称：

  Synthesis of 1-Mono- and 1,3-Di-Substituted 6-Aminouracils. Diuretic Activity

  摘要：

  DOI：

  10.1021/jo50006a010

文献信息

• 3-alkenylxanthines and their lower 1-alkyl derivatives
  申请人：SEARLE & CO

  公开号：US02673848A1

  公开（公告）日：1954-03-30
• Synthesis of 1-Mono- and 1,3-Di-Substituted 6-Aminouracils. Diuretic Activity
  作者：Victor Papesch、Elmer F. Schroeder

  DOI：10.1021/jo50006a010

  日期：1951.12
• Inhibition of separated forms of cyclic nucleotide phosphodiesterase from pig coronary arteries by 1,3-disubstituted and 1,3,8-trisubstituted xanthines
  作者：Jack N. Wells、John E. Garst、George L. Kramer

  DOI：10.1021/jm00140a008

  日期：1981.8

  A series of xanthines with varied substituents in the 1, 3, and 8 positions were prepared in an attempt to understand the structure--activity relationship for alkylxanthines as inhibitors of two different forms of cyclic nucleotide phosphodiesterase. Polar substituents on the 1 or 3 position of the xanthine reduced the potency of the xanthines to inhibit both the calmodulin-sensitive and the "cyclic AMP specific" forms of phosphodiesterase. Polar substituents on the 8 position of the xanthine, other than a carboxylic acid, increased the potency to inhibit the calmodulin-sensitive form of phosphodiesterase, if they were capable of donating electrons to the xanthine nucleus. On the other hand, any substituent in the 8 position larger than H reduced the potency of the xanthines to inhibit the cyclic AMP specific form of phosphodiesterase. Topographical maps of the active sites of the two forms of phosphodiesterase are presented in summary.