5,6-diamino-3-methy-1-propenylluracil | 90749-75-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5,6-diamino-3-methy-1-propenylluracil
• 英文别名: 5,6-Diamino-1-allyl-3-methyl-1H-pyrimidine-2,4-dione；5,6-diamino-3-methyl-1-prop-2-enylpyrimidine-2,4-dione
• CAS: 90749-75-0
• 化学式: C₈H₁₂N₄O₂
• 分子量: 196.209
• InChiKey: SRVHQLWVVTWHSL-UHFFFAOYSA-N

物化性质

• 沸点：
  278.2±50.0 °C(Predicted)
• 密度：
  1.264±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5,6-diamino-3-methy-1-propenylluracil 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 26.0h， 生成 8-(3-methoxypropyl)-1-methyl-3-prop-2-enyl-7H-purine-2,6-dione
  参考文献：
  名称：

  New xanthine derivatives with potent and long lasting anti-bronchoconstrictive activity

  摘要：

  DOI：

  10.1016/0223-5234(87)90056-0
• 作为产物：
  描述：

  1-allyl-3-methyl-5-nitroso-6-amino uracil 在 Raney-NiW-2 氢气 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以96%的产率得到5,6-diamino-3-methy-1-propenylluracil
  参考文献：
  名称：

  New xanthine derivatives with potent and long lasting anti-bronchoconstrictive activity

  摘要：

  DOI：

  10.1016/0223-5234(87)90056-0

文献信息

• De Araujo, Aline D.; Bacher, Edmond; Joachim Demnitz, Heterocycles, 1999, vol. 51, # 1, p. 29 - 36
  作者：De Araujo, Aline D.、Bacher, Edmond、Joachim Demnitz、Santos, Douglas A.

  DOI：——

  日期：——
• Inhibition of separated forms of cyclic nucleotide phosphodiesterase from pig coronary arteries by 1,3-disubstituted and 1,3,8-trisubstituted xanthines
  作者：Jack N. Wells、John E. Garst、George L. Kramer

  DOI：10.1021/jm00140a008

  日期：1981.8

  A series of xanthines with varied substituents in the 1, 3, and 8 positions were prepared in an attempt to understand the structure--activity relationship for alkylxanthines as inhibitors of two different forms of cyclic nucleotide phosphodiesterase. Polar substituents on the 1 or 3 position of the xanthine reduced the potency of the xanthines to inhibit both the calmodulin-sensitive and the "cyclic AMP specific" forms of phosphodiesterase. Polar substituents on the 8 position of the xanthine, other than a carboxylic acid, increased the potency to inhibit the calmodulin-sensitive form of phosphodiesterase, if they were capable of donating electrons to the xanthine nucleus. On the other hand, any substituent in the 8 position larger than H reduced the potency of the xanthines to inhibit the cyclic AMP specific form of phosphodiesterase. Topographical maps of the active sites of the two forms of phosphodiesterase are presented in summary.
• REGNIER, G. L.;SAINT-ROMAS, C. G.;DUHAULT, J. L.;TISSERAND, F. P.;SAINT-R+, EUR. J. MED. CHEM., 22,(1987) N 3, 243-250
  作者：REGNIER, G. L.、SAINT-ROMAS, C. G.、DUHAULT, J. L.、TISSERAND, F. P.、SAINT-R+

  DOI：——

  日期：——
• New xanthine derivatives with potent and long lasting anti-bronchoconstrictive activity
  作者：Gilbert L Regnier、Claude G Guillonneau、Jacques L Duhault、Françoise P Tisserand、Guy Saint-Romas、Sophie M Holstorp

  DOI：10.1016/0223-5234(87)90056-0

  日期：1987.5