11-amino-11-N,12-O-carbonyl-4''-O-(3-{2-[3-(3-carboxy-1-ethyl-4-oxo-1,4-dihydro-quinolin-6-yl)-propoxy]-ethoxy}-propiony)-11-desoxy-6-O-methyl-erythromycin A | 1253591-50-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 11-amino-11-N,12-O-carbonyl-4''-O-(3-{2-[3-(3-carboxy-1-ethyl-4-oxo-1,4-dihydro-quinolin-6-yl)-propoxy]-ethoxy}-propiony)-11-desoxy-6-O-methyl-erythromycin A
• CAS: 1253591-50-2
• 化学式: C₅₉H₉₁N₃O₁₉
• 分子量: 1146.38
• InChiKey: GVISLCSRCAKUIQ-LCCFKCJKSA-N

反应信息

• 作为产物：
  描述：

  在 甲醇 作用下， 反应 24.0h， 生成 11-amino-11-N,12-O-carbonyl-4''-O-(3-{2-[3-(3-carboxy-1-ethyl-4-oxo-1,4-dihydro-quinolin-6-yl)-propoxy]-ethoxy}-propiony)-11-desoxy-6-O-methyl-erythromycin A
  参考文献：
  名称：

  Synthesis and biological activity of 4″-O-acyl derivatives of 14- and 15-membered macrolides linked to ω-quinolone-carboxylic unit

  摘要：

  The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quinolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural properties of lead compound 26 are discussed. Promising antibacterial properties of this compound and some of its analogues are reported. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.06.050