dodecyl O-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid | 1186201-38-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dodecyl O-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid
• CAS: 1186201-38-6
• 化学式: C₅₆H₉₄N₄O₃₂S
• 分子量: 1367.44
• InChiKey: FUPLNNLEWUUDPA-MNBPJUTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.69
• 重原子数：
  93.0
• 可旋转键数：
  38.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  593.2
• 氢给体数：
  21.0
• 氢受体数：
  29.0

反应信息

• 作为产物：
  描述：

  (dodecyl 5-acetamido-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-2-nonulopyranosid)onic acid 、 cytidine-5'-monophospho-β-D-N-acetylneuraminic acid, disodium salt 在 CST-II (α-2,8-sialyltransferase) from Campylobacter jejuni OH4384 、 manganese(ll) chloride 、 alkaline phosphatase 作用下， 反应 24.0h， 以12.4%的产率得到dodecyl O-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonic acid)-(2->8)-5-acetamido-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid
  参考文献：
  名称：

  Probing a sialyltransferase’s recognition domain to prepare α(2,8)-linked oligosialosides and analogs

  摘要：

  我们首次观察到，单唾液酸残基是酶CST-II识别的关键结构要素；这一发现为一步合成一系列α(2,8)-连接的寡唾液酸及其硫代类似物开辟了一条有吸引力的途径。

  DOI：

  10.1039/b908933k

文献信息

• CST-II’s recognition domain for acceptor substrates in α-(2→8)-sialylations
  作者：Wenling Li、Ping Zhang、Amir J. Zuccolo、Ruxiang Blake Zheng、Chang-Chun Ling

  DOI：10.1016/j.carres.2011.05.009

  日期：2011.9

  CST-II is a bacterial sialyltransferase known for its ability to perform alpha-(2 -> 8)-sialylations using GM(3) related trisaccharide substrates. Previously, we probed the enzyme's substrate specificity and developed an efficient synthesis for alpha-(2 -> 8)-oligosialosides, and we suggested that CST-II could have a very small substrate recognition domain. Here we report our full studies on CST-II's recognition feature for acceptor substrates. The current study further demonstrates the versatility of CST-II in preparing complex oligosaccharides that contain alpha-(2 -> 8)-oligosialyl moieties. (C) 2011 Elsevier Ltd. All rights reserved.