4-[4-(羟甲基)苯氧基]丁酸乙酯 | 174884-11-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-[4-(羟甲基)苯氧基]丁酸乙酯
• 中文别名: 丁酸,4-[4-(羟甲基)苯氧基]-,乙基酯
• 英文名称: ethyl 4-(4-(hydroxymethyl)phenoxy) butanoate
• 英文别名: Ethyl 4-(4-(hydroxymethyl)phenoxy)butanoate；ethyl 4-[4-(hydroxymethyl)phenoxy]butanoate
• CAS: 174884-11-8
• 化学式: C₁₃H₁₈O₄
• 分子量: 238.284
• InChiKey: LPLPUZDQDMOIMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[4-(羟甲基)苯氧基]丁酸乙酯 在 咪唑 、 碘 、 三苯基膦 作用下， 以 乙腈 为溶剂， 反应 0.33h， 生成 ethyl 4-[4-(iodomethyl)phenoxy]butanoate
  参考文献：
  名称：

  WO2006/17055

  摘要：

  公开号：
• 作为产物：
  描述：

  对羟基苯甲醛 在 potassium carbonate 作用下， 以 aq. phosphate buffer 、 乙腈 为溶剂， 反应 32.0h， 生成 4-[4-(羟甲基)苯氧基]丁酸乙酯
  参考文献：
  名称：

  醛自动氧化可实现化学选择性和位点选择性肽修饰以及天然蛋白质修饰

  摘要：

  我们报道了天然蛋白质中ε-胺的化学选择性和位点选择性甲酰化。醛的自动氧化路线，可调节的甲酸盐生成和可逆的N末端保护作用推动了这一转变。它标记了...

  DOI：

  10.1039/c6cc09555k
• 作为试剂：
  描述：

  对羟基苯甲醇 、 4-溴丁酸乙酯 、 在 4-[4-(羟甲基)苯氧基]丁酸乙酯 作用下， 以The ester 29b was isolated as colorless oil 96% yield (2.26 g)的产率得到4-[4-(羟甲基)苯氧基]丁酸乙酯
  参考文献：
  名称：

  Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors

  摘要：

  本发明提供了新型吲哚酮衍生物，可优势地用于治疗和/或预防需要抑制胆碱酯酶的医疗状况。

  公开号：

  US08580822B2

文献信息

• Trifluoroacetylalkyl-substituted phenyl, phenol and benzoyl compounds and related methods of treatment
  申请人：SOLVAY PHARMACEUTICALS GMBH

  公开号：US20040214901A1

  公开（公告）日：2004-10-28

  Novel and known trifluoroacetyl-substituted phenyl, phenol and benzoyl compounds for the treatment and/or inhibition of obesity and of concomitant and/or secondary diseases involved therewith, in particular metabolic syndrome and cardiovascular diseases. Novel trifluoroacetyl-substituted phenyl, phenol and benzoyl compounds, pharmaceutical preparations containing them and processes for the preparation of these compounds. Also compounds acting as inhibitors of lipase, in particular pancreatic lipase.

  用于治疗和/或抑制肥胖症及其相关和/或继发疾病，特别是代谢综合征和心血管疾病的新型和已知的三氟乙酰基取代苯、苯酚和苯甲酰化合物。新型的三氟乙酰基取代苯、苯酚和苯甲酰化合物、含有它们的制药制剂以及制备这些化合物的过程。还有作为脂肪酶抑制剂，特别是胰脂肪酶抑制剂的化合物。
• Enediyne derivatives useful for the synthesis of conjugates of
  申请人：American Cyanamid Company

  公开号：US05739116A1

  公开（公告）日：1998-04-14

  This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

  本发明描述了由卡利切阿霉素家族的二硫键类似物及其衍生物制备的载体-药物共轭物，以及来自相关抗肿瘤抗生素如埃斯佩拉霉素的类似物。载体可以是抗体、生长因子或类固醇，其针对不需要的细胞群体，例如肿瘤细胞。整个蛋白质载体以及其抗原识别片段及其化学或基因操作的对应物对该共轭物的靶向部分非常有用。本发明包括合成这些共轭物所需的化合物、载体-药物共轭物的适当制药组合物以及它们的使用方法。
• Conjugates of methyltrithio antitumor agents and intermediates for their
  申请人：American Cyanamid Company

  公开号：US05773001A1

  公开（公告）日：1998-06-30

  This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

  本发明描述了由卡利奇阿霉素家族的二硫化物类似物及其衍生物制备的载体-药物共轭物，以及来自相关抗肿瘤抗生素（如埃斯佩拉霉素）的类似物。载体可以是抗体、生长因子或类固醇，其靶向不需要的细胞群体，如肿瘤细胞。整个蛋白质载体以及其抗原识别片段和其化学或基因操作的对应物对共轭物的靶向部分都有用。本发明包括合成这些共轭物所需的化合物、载体-药物共轭物的适当药物组成以及它们的使用方法。
• Linkers useful for the synthesis of conjugates of methyltrithio
  申请人：American Cyanamid Company

  公开号：US05767285A1

  公开（公告）日：1998-06-16

  This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

  本发明描述了由强效抗肿瘤抗生素calicheamicin家族的二硫键类似物及其衍生物以及类似的esperamicins的类似物制备的载体-药物共轭物，载体可以是抗体、生长因子或类固醇，其针对不需要的细胞群体，例如肿瘤细胞。整个蛋白质载体以及它们的抗原识别片段和它们的化学或基因操作的对应物对于共轭物的靶向部分是有用的。本发明包括用于这些共轭物的合成所需的化合物，载体-药物共轭物的适当药物组成以及它们的使用方法。
• Process for preparing conjugates of methyltrithio antitumor agents
  申请人：American Cyanamid Company

  公开号：US05877296A1

  公开（公告）日：1999-03-02

  This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

  本发明描述了从卡利切阿霉素家族的二硫化物类似物及其衍生物以及类似的抗肿瘤抗生素如埃斯佩拉霉素中制备的载体-药物结合物，载体可以是抗体、生长因子或类固醇，其靶向不需要的细胞群体，例如肿瘤细胞。整个蛋白质载体以及其抗原识别片段以及其化学或基因操纵的对应物对于结合物的靶向部分是有用的。本发明包括合成这些结合物所需的化合物，载体-药物结合物的适当药物组成以及它们的使用方法。