| 25907-11-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 25907-11-3
• 化学式: C₆H₁₃O₉S*Na
• 分子量: 284.22
• InChiKey: BJVULXFVKRSXSX-BMZZJELJSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -7.71
• 重原子数：
  17.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  178.58
• 氢给体数：
  6.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  在 phosphate buffer 作用下， 以 水 为溶剂， 生成 葡萄糖 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Stability of Human Insulin in Solutions Containing Sodium Bisulfite.

  摘要：

  The stabilities of human insulin (HI) is aqueous solutions were investigated in the pH range of 4.0-7.0 in the presence (1.0-3.0×10-3M) and absence of sodium bisulfite (SBS) both in the dark and under scattered light (1000 lux) using high performance liquid chromatography. Increasing concentrations of SBS tended to degrade HI. In the presence of SBS, with an increase in the pH value, the stability of HI decreased in the pH range of 4.0-7.0. There was a partial difference in the stability of HI in the presence of SBS in the dark and that under scattered light.HI was stabilized by glycose in the presence of SBS in the dark, and the stability of HI was revealed to depend on the concentration of free SBS. The reason for this phenomenon was postulated to be the formation of bisulfite-glucose adduct.

  DOI：

  10.1248/cpb.39.2662
• 作为产物：
  描述：

  葡萄糖 在 phosphate buffer 、 sodium hydrogensulfite 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Stability of Human Insulin in Solutions Containing Sodium Bisulfite.

  摘要：

  The stabilities of human insulin (HI) is aqueous solutions were investigated in the pH range of 4.0-7.0 in the presence (1.0-3.0×10-3M) and absence of sodium bisulfite (SBS) both in the dark and under scattered light (1000 lux) using high performance liquid chromatography. Increasing concentrations of SBS tended to degrade HI. In the presence of SBS, with an increase in the pH value, the stability of HI decreased in the pH range of 4.0-7.0. There was a partial difference in the stability of HI in the presence of SBS in the dark and that under scattered light.HI was stabilized by glycose in the presence of SBS in the dark, and the stability of HI was revealed to depend on the concentration of free SBS. The reason for this phenomenon was postulated to be the formation of bisulfite-glucose adduct.

  DOI：

  10.1248/cpb.39.2662