2-(dodecanoylamino)-5-hydroxy-5-oxopentanoate;tris(2-hydroxyethyl)azanium | 53576-64-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(dodecanoylamino)-5-hydroxy-5-oxopentanoate;tris(2-hydroxyethyl)azanium
• CAS: 53576-64-0
• 化学式: C₆H₁₅NO₃*C₁₇H₃₁NO₅
• 分子量: 478.627
• InChiKey: ACCAIGJKLCJFHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.61
• 重原子数：
  33
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  172
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  月桂酸 、 三乙醇胺 、 DL-谷氨酸 在 bis(perfluorohexylsulfonic acid) zirconocene 作用下， 以 水 、 丙酮 为溶剂， 反应 25.0h， 以73%的产率得到2-(dodecanoylamino)-5-hydroxy-5-oxopentanoate;tris(2-hydroxyethyl)azanium
  参考文献：
  名称：

  一种基于锆催化剂催化合成N-酰基氨基酸表面活性剂的方法

  摘要：

  本发明公开了一种基于锆催化剂催化合成N‑酰基氨基酸表面活性剂的方法，该方法是将长链脂肪羧酸与氨基酸和/或氨基酸盐在二(全氟己基磺酸)二茂锆催化作用下进行缩合反应，即得N‑酰基氨基酸表面活性剂。该方法操作简单，无需通过酰氯中间体转化，无高盐废水产生，且反应条件温和，目标产物收率高，官能团耐受范围广。

  公开号：

  CN114031516B

文献信息

• Transparent biphase composition for topical application
  申请人：L'OREAL

  公开号：US20040192832A1

  公开（公告）日：2004-09-30

  The invention relates to a composition, which can be used for cosmetic purposes such as hair and skin care, the composition having a distinct aqueous phase and a distinct oily phase, the aqueous phase comprising at least 40% by weight with respect to the total weight of the aqueous phase of one or more polyols, and the oily phase comprising at least 5% by weight with respect to the total weight of the oily phase of one or more silicone oils, wherein the quantity of polyols and the quantity of silicone oils being such that the refractive indices of the two phases are substantially identical.

  本发明涉及一种组合物，可用于化妆品用途，如头发和皮肤护理，该组合物具有明显的水相和明显的油相，水相包含至少40%的聚醇，相对于水相的总重量，油相包含至少5%的硅油，相对于油相的总重量，聚醇和硅油的数量使得两相的折射率几乎相同。
• Amino acid derivatives and compositions containing the same for inhibiting active-oxygen
  申请人：Ajinomoto Co., Inc.

  公开号：EP0869115A2

  公开（公告）日：1998-10-07

  A novel active oxygen-resisting agent is provided which has an excellent active oxygen resistance and which exhibits a good solubility in an oil solvent. The active oxygen-resisting agent contains as an active ingredient an amino acid derivative represented by the following formula (I) or its salt wherein Ar represents a 2-hydroxyphenyl group or a pyridyl group (one or more of hydrogen atoms bound to the aromatic rings of these groups may be substituted independently with a halogen atom, an alkyl group having from 1 to 6 carbon atoms, a hydroxyl group, a hydroxyalkyl group having from 1 to 6 carbon atoms, a nitro group, an alkoxyl group having from 1 to 6 carbon atoms or a carboxyl group), R1 represents a side chain of an animo acid, X represents -O- or -NH-, R2 represents an alkyl group having from 8 to 22 carbon atoms, and n represents 0 or 1.

  本发明提供了一种新型活性抗氧剂，它具有极佳的活性抗氧性，并且在油溶剂中具有良好的溶解性。 该活性抗氧剂的活性成分是由下式（I）或其盐代表的氨基酸衍生物 其中 Ar 代表 2-羟基苯基或吡啶基（与这些基团的芳香环结合的一个或多个氢原子可独立地被卤素原子、1-6 个碳原子的烷基、羟基、1-6 个碳原子的羟烷基、硝基、1-6 个碳原子的烷氧基或羧基取代）、 R1 代表亚胺酸的侧链、 X 代表-O-或-NH-、 R2 代表具有 8 至 22 个碳原子的烷基，以及 n 代表 0 或 1。
• Nonionic surfactant
  申请人：Ajinomoto Co., Inc.

  公开号：EP0913390A2

  公开（公告）日：1999-05-06

  Herein are disclosed N-long chain acyl-neutral amino acid polyglycerin esters composed of a polyglycerin having a degree of glycerin polymerization of not smaller than 4 and an N-long chain acyl-neutral amino acid having an acyl group with from 6 to 22 carbon atoms and a nonionic surfactant composition comprising, as an active ingredient, at least one of said N-long chain acyl-neutral amino acid polyglycerin esters, which are favorably safe and which, when incorporated in cosmetic compositions or percutaneous preparations, are sensorially good.

  本发明公开了由甘油聚合度不小于 4 的聚甘油和具有 6 至 22 个碳原子的酰基的 N 长链酰基中性氨基酸组成的 N 长链酰基中性氨基酸聚甘油酯以及非离子表面活性剂组合物，该组合物包括、作为活性成分的至少一种所述 N-长链酰基中性氨基酸聚甘油酯，具有良好的安全性，当加入化妆品组合物或经皮制剂中时，具有良好的感官效果。
• Amino acid derivatives and anti-inflammatory agents
  申请人：Ajinomoto Co., Inc.

  公开号：EP0955046A2

  公开（公告）日：1999-11-10

  Provided are an anti-inflammatory agent containing, as an active ingredient, at least one selected from amino acid derivatives represented by formula (I) wherein Ar represents an optionally substituted 2-hydroxyaryl group, n is 0 or 1, R2 represents a hydrogen atom or a side chain of an α-amino acid or a β-amino acid, X represents -0- or -NH-, R1 represents a hydrogen atom or a group that forms, together with R2 and an adjacent atoms, a cyclic structure of pyroglutamic acid, and R3 represents a hydrogen atom, an alkyl group having from 1 to 22 carbon atoms or an alkenyl group having from 2 to 22 carbon atoms, and salts thereof, and toiletries or skin external products containing the same. The anti-inflammatory agent of the invention inhibits expression of an inflammatory protein and activation of a gene transcription control factor that participates therein, and exhibits a good feeling upon use and a safety.

  提供了一种抗炎剂，其中含有至少一种选自式 (I) 所代表的氨基酸衍生物的活性成分 其中 Ar 代表任选取代的 2-羟基芳基，n 为 0 或 1，R2 代表氢原子或 α-氨基酸或 β-氨基酸的侧链，X 代表 -0- 或 -NH-，R1 代表氢原子或与 R2 和相邻原子一起形成焦谷氨酸环状结构的基团，R3 代表氢原子、具有 1 至 22 个碳原子的烷基或具有 2 至 22 个碳原子的烯基、 及其盐类，以及含有这些成分的洗浴用品或皮肤外用产品。 本发明的抗炎剂可抑制炎症蛋白的表达和参与其中的基因转录控制因子的活化，使用时感觉良好，安全性高。
• CYSTEINE DERIVATIVES
  申请人：Ajinomoto Co., Inc.

  公开号：EP1120407A1

  公开（公告）日：2001-08-01

  Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.

  本发明的目的是提供一种氧化应激抑制剂，它能够抑制细胞毒性蛋白的表达和参与细胞毒性蛋白表达的基因转录调控因子的活化，并在使用时具有良好的感觉和安全性；提供一种方法，用于预防、延缓、减轻或治疗由氧化应激引起或促进的皮肤老化变化或皮肤美容方面的不良变化；以及提供一种外用化妆品组合物或皮肤病制剂，其中包含作为有效成分的氧化应激抑制剂，并为此目的采用一种氧化应激抑制剂，其中包含作为有效成分的至少一种选自半胱氨酸或胱氨酸衍生物及其盐类的氧化应激抑制剂。