Methyl 2-(hydroxymethyl)-2-[(4-methoxyphenyl)methylamino]-3-phenylmethoxypropanoate | 1263179-71-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-(hydroxymethyl)-2-[(4-methoxyphenyl)methylamino]-3-phenylmethoxypropanoate
• CAS: 1263179-71-0
• 化学式: C₂₀H₂₅NO₅
• 分子量: 359.422
• InChiKey: VSYNWXAELFUDCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  77
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  甲酸 、 Methyl 2-(hydroxymethyl)-2-[(4-methoxyphenyl)methylamino]-3-phenylmethoxypropanoate 在 乙酸酐 作用下， 生成
  参考文献：
  名称：

  Synthetic studies of salinosporamide A through the intramolecular hydroamidation of alkynes

  摘要：

  Rhodium-catalyzed intramolecular hydroamidation of alkynes was carried out to construct the synthetic intermediates of a proteasome inhibitor, salinosporamide A. Several alkynyl formamides were synthesized and subjected to the hydroamidation reaction. Some derivatives with a methoxymethyl (MOM) or 2-methoxy-2-propyl (MOP) group near the reaction site were converted to the corresponding lactams in excellent yields. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.06.021
• 作为产物：
  描述：

  methyl (S)-2-(4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxylate 、 苄基氯甲基醚 在 六甲基磷酰三胺 、 lithium diisopropyl amide 、 sodium cyanoborohydride 、 溶剂黄146 作用下， 以43%的产率得到Methyl 2-(hydroxymethyl)-2-[(4-methoxyphenyl)methylamino]-3-phenylmethoxypropanoate
  参考文献：
  名称：

  Synthetic studies of salinosporamide A through the intramolecular hydroamidation of alkynes

  摘要：

  Rhodium-catalyzed intramolecular hydroamidation of alkynes was carried out to construct the synthetic intermediates of a proteasome inhibitor, salinosporamide A. Several alkynyl formamides were synthesized and subjected to the hydroamidation reaction. Some derivatives with a methoxymethyl (MOM) or 2-methoxy-2-propyl (MOP) group near the reaction site were converted to the corresponding lactams in excellent yields. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.06.021

文献信息

• Synthetic studies of salinosporamide A through the intramolecular hydroamidation of alkynes
  作者：Haruhi Kamisaki、Yusuke Kobayashi、Tetsutaro Kimachi、Yoshizumi Yasui、Yoshiji Takemoto

  DOI：10.1016/j.jorganchem.2010.06.021

  日期：2011.1

  Rhodium-catalyzed intramolecular hydroamidation of alkynes was carried out to construct the synthetic intermediates of a proteasome inhibitor, salinosporamide A. Several alkynyl formamides were synthesized and subjected to the hydroamidation reaction. Some derivatives with a methoxymethyl (MOM) or 2-methoxy-2-propyl (MOP) group near the reaction site were converted to the corresponding lactams in excellent yields. (C) 2010 Elsevier B.V. All rights reserved.