5-(1H-Imidazol-2-ylthio)-3-methyl-1-(2-methylpropyl)-6-[2-(trifluoromethyl)benzoyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione | 372162-36-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(1H-Imidazol-2-ylthio)-3-methyl-1-(2-methylpropyl)-6-[2-(trifluoromethyl)benzoyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
• 英文别名: 5-(1H-imidazol-2-ylsulfanyl)-3-methyl-1-(2-methylpropyl)-6-[2-(trifluoromethyl)benzoyl]thieno[2,3-d]pyrimidine-2,4-dione
• CAS: 372162-36-2
• 化学式: C₂₂H₁₉F₃N₄O₃S₂
• 分子量: 508.545
• InChiKey: AEVYTHWPCCSCIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  140
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Thieno[2,3-d]pyrimidinediones and their use as pharmaceuticals
  申请人：——

  公开号：US20040014634A1

  公开（公告）日：2004-01-22

  The invention provides thieno[2,3-d]pyrimidinediones of general formula (I), wherein R, R 1 , R 2 and R 3 are as defined in the specification, processes for their production, pharmaceutical compositions containing them and their use in therapy. 1

  这项发明提供了通式（I）中的噻吩[2,3-d]嘧啶二酮，其中R、R1、R2和R3如规范中定义，其生产方法，含有它们的药物组合物以及它们在治疗中的用途。
• THIENO 2,3-d]PYRIMIDINEDIONES AND THEIR USE AS PHARMACEUTICALS
  申请人：AstraZeneca AB

  公开号：EP1280806B1

  公开（公告）日：2004-08-04
• [EN] THIENO[2,3-d]PYRIMIDINEDIONES AND THEIR USE AS PHARMACEUTICALS<br/>[FR] THIENO[2,3-D]PYRIMIDINEDIONES ET LEUR UTILISATION EN TANT QUE PRODUITS PHARMACEUTIQUES
  申请人：ASTRAZENECA AB

  公开号：WO2001083489A1

  公开（公告）日：2001-11-08

  The invention provides thieno[2,3-d]pyrimidinediones of general formula (I), wherein R, R?1, R2 and R3¿ are as defined in the specification, processes for their production, pharmaceutical compositions containing them and their use in therapy.