(1S,6aS,9R,10aR,11aS)-6,6,9-trimethyl-1-(oct-1-yn-1-yl)octahydro-6H-[1,4]oxazino[3,4-b][1,3]benzoxazin-3(4H)-one | 1277183-27-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1S,6aS,9R,10aR,11aS)-6,6,9-trimethyl-1-(oct-1-yn-1-yl)octahydro-6H-[1,4]oxazino[3,4-b][1,3]benzoxazin-3(4H)-one
• 英文别名: (3S,6R,8R,10S,11S)-2,2,6-trimethyl-11-oct-1-ynyl-9,12-dioxa-1-azatricyclo[8.4.0.03,8]tetradecan-13-one
• CAS: 1277183-27-3
• 化学式: C₂₂H₃₅NO₃
• 分子量: 361.525
• InChiKey: TUCJFAZOJKMROS-YRIDSSQKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1S,6aS,9R,10aR,11aS)-6,6,9-trimethyl-1-(oct-1-yn-1-yl)octahydro-6H-[1,4]oxazino[3,4-b][1,3]benzoxazin-3(4H)-one 在 四甲基乙二胺 、 氢气 、 nickel(II) acetate tetrahydrate 作用下， 以 乙醇 为溶剂， 以77%的产率得到(1S,6aS,9R,10aR,11aS)-6,6,9-trimethyl-1-[(1Z)-oct-1-en-1-yl]octahydro-6H-[1,4]oxazino[3,4-b][1,3]benzoxazin-3(4H)-one
  参考文献：
  名称：

  A Stereoselective Approach to γ-Functionalized Carbonyls Exploiting the Cu-Promoted S_N2′ Reaction

  摘要：

  While several efficient processes exist to effect the stereoselective creation of carbon-carbon bonds in the alpha- and beta-position of carbonyls, functionalization of the gamma-position is much more challenging. We disclose an alternative methodology exploiting the Cu-promoted S(N)2' reaction to achieve the addition of various nucleophiles upon the allylic lactones 5a-d which lead to the generation of the desired y-functionalized alpha,beta-unsaturated aldehydes 6 following in situ hydrolysis.

  DOI：

  10.1021/jo102213d
• 作为产物：
  描述：

  ({2-[(1S,2R,4R)-2-Hydroxy-4-methylcyclohexyl]propan-2-yl}amino)acetic acid 在 sodium hydride 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 mineral oil 为溶剂， 反应 1.25h， 生成 (1S,6aS,9R,10aR,11aS)-6,6,9-trimethyl-1-(oct-1-yn-1-yl)octahydro-6H-[1,4]oxazino[3,4-b][1,3]benzoxazin-3(4H)-one 、 (1R,6aS,9R,10aR,11aS)-6,6,9-trimethyl-1-(oct-1-yn-1-yl)octahydro-6H-[1,4]oxazino[3,4-b][1,3]benzoxazin-3(4H)-one
  参考文献：
  名称：

  A Stereoselective Approach to γ-Functionalized Carbonyls Exploiting the Cu-Promoted S_N2′ Reaction

  摘要：

  While several efficient processes exist to effect the stereoselective creation of carbon-carbon bonds in the alpha- and beta-position of carbonyls, functionalization of the gamma-position is much more challenging. We disclose an alternative methodology exploiting the Cu-promoted S(N)2' reaction to achieve the addition of various nucleophiles upon the allylic lactones 5a-d which lead to the generation of the desired y-functionalized alpha,beta-unsaturated aldehydes 6 following in situ hydrolysis.

  DOI：

  10.1021/jo102213d

文献信息

• A Stereoselective Approach to γ-Functionalized Carbonyls Exploiting the Cu-Promoted S_N2′ Reaction
  作者：Eric Bond、Anne-Marie Beausoleil、Jennifer Howell、Alicia Wong、Joël Robichaud

  DOI：10.1021/jo102213d

  日期：2011.4.15

  While several efficient processes exist to effect the stereoselective creation of carbon-carbon bonds in the alpha- and beta-position of carbonyls, functionalization of the gamma-position is much more challenging. We disclose an alternative methodology exploiting the Cu-promoted S(N)2' reaction to achieve the addition of various nucleophiles upon the allylic lactones 5a-d which lead to the generation of the desired y-functionalized alpha,beta-unsaturated aldehydes 6 following in situ hydrolysis.