20α-Hydroxy-des-A-Δ⁹-pregnen-5-on | 15267-19-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 20α-Hydroxy-des-A-Δ⁹-pregnen-5-on
• 英文别名: (3S,3aS,9aS,9bS)-3-[(1S)-1-hydroxyethyl]-3a,6-dimethyl-2,3,4,5,8,9,9a,9b-octahydro-1H-cyclopenta[a]naphthalen-7-one
• CAS: 15267-19-3
• 化学式: C₁₇H₂₆O₂
• 分子量: 262.392
• InChiKey: QPQZNKJKOLBKNV-XCALXHAASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Process for the preparation of 9 beta,10 alpha-progesterone (retroprogesterone)
  申请人：INDUSTRIALE CHIMICA S.R.L.

  公开号：US10654885B2

  公开（公告）日：2020-05-19

  The present invention refers to a new process for the synthesis of (9β,10α)-pregn-4-ene-3,20-dione, commonly known as retroprogesterone, having the formula (1) shown below.

  本发明涉及一种合成(9β,10α)-孕甾-4-烯-3,20-二酮（俗称逆孕酮）的新工艺，其式（1）如下所示。
• PROCESS FOR THE PREPARATION OF 9 BETA,10 ALPHA-PROGESTERONE (RETROPROGESTERONE)
  申请人：INDUSTRIALE CHIMICA S.R.L.

  公开号：US20200040029A1

  公开（公告）日：2020-02-06

  The present invention refers to a new process for the synthesis of (9β,10α)-pregn-4-ene-3,20-dione, commonly known as retroprogesterone, having the formula (1) shown below.