(2,2'-dipyridylketone)platinum(II) chloride | 77883-92-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,2'-dipyridylketone)platinum(II) chloride
• 英文别名: 2,2'-dipyridylketonedichloroplatinum(II)；{Pt(dpk)Cl2}；oxiplatin；[PtCl2(2,2'-dipyridylketone)]；[Pt(di-2-pyridyl ketone)Cl2]；[PtCl2(di-2-pyridyl ketone)]
• CAS: 77883-92-2
• 化学式: C₁₁H₈Cl₂N₂OPt
• 分子量: 450.183
• InChiKey: FITDMWPRBQOHKM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  (2,2'-dipyridylketone)platinum(II) chloride 在 water 作用下， 以 水 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  质子分子可逆地添加到钯（II），铂（II）和金（III）配合物中的配位二-2-吡啶基酮中 二氯（二羟基-二-2-吡啶基甲烷）钯（II）和氯化二氯（二羟基-二-2-吡啶基甲烷）金（III）的X射线晶体结构

  摘要：

  钯（II），铂（II）和金（III）物种与二-2-吡啶基酮（dpk）反应生成复合物，其中原始酮基或新形成的diolic形式的一个或两个配体分子为与金属阳离子配位，即：[PdCl 2（dpk·HX）] [X = OH（1），OMe（2）或OEt（3）]；[PdCl 2（dpk）]，（4）；[ M + H] +。[Pd（dpk·H 2 O）2 ] [ClO 4 ] 2，（5）；[Pd（dpk·H 2 O）2 ] 。[PtCl 2（dpk）]，（6）；[PtCl 2（dpk）]，（6）。[AuCl 2（dpk·H 2 O）] Cl，（7）；m / z 。和[Au（dpk·H 2 O）2 ] [ClO 4 ] 3，（8）。在溶液中，所有物种都会根据HX的浓度经历质子分子的添加或释放。从Pt II到Pd II再到Au III，可逆水解的速率和水合物种的稳定性增加，因此与金属阳离子的吸电子特性和它们填

  DOI：

  10.1039/dt9810002280
• 作为产物：
  描述：

  2-二吡啶基酮 以 乙醚 、 二氯甲烷-D2 为溶剂， 生成 (2,2'-dipyridylketone)platinum(II) chloride
  参考文献：
  名称：

  Trimethylsilylplatinum(IV) complexes as reaction intermediates

  摘要：

  The oxidative addition of I-2, PhCH2Br and MeI with [Pt(CH2SiMe3)(2)(DPK)], 1, DPK = di-2-pyridyl ketone, occurred with trans stereochemistry to give [PtI2(CH2SiMe3)(2)(DPK)], [PtBr(CH2Ph)(CH2SiMe3)(2)(DPK)] and [PtIMe(CH2SiMe3)(2)(DPK)], respectively. Complex 1 reacted with acids HX (X = Cl or CF3CO2) to give initially the hydridoplatinum complexes [PtHX(CH2SiMe3)(2)(DPK)], but these complexes were thermally unstable and decomposed largely by alpha-silyl migration to give compounds such as [PtX(SiMe3)Me-2(DPK)], as determined by monitoring the reactions by NMR at low temperature. With excess acid, HX, at room temperature, the products were largely [PtX2(DPK)], CH4 and Me3SiX with Me4Si as a minor product only. The mechanism of the easy Si-CH2 bond cleavage is discussed. (C) 2010 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2010.11.018

文献信息

• Synthesis, Characterization, and Photophysical Properties of Three Platinum(II) Complexes Bearing Fluorescent Analogues of the Di-2-pyridylmethane Ligand
  作者：Justin J. Wilson、Juliana Fedoce Lopes、Stephen J. Lippard

  DOI：10.1021/ic100411p

  日期：2010.6.7

  1 thermally decomposes at 60 °C to form several unidentified products. Compound 2 is thermally stable even in the presence of dioxygen and water but upon light exposure decomposes to form a new platinum(II) species with a 195Pt NMR shift of −2177 ppm. Compound 3 reacts both thermally and photochemically in the presence of dioxygen and trace amounts of water to form both 4-amino-7-nitro-2,1,3-benzoxadiazole

  通式 [RNHCH(py) 2 ] 的三个新配体（py = 吡啶；R = 甲苯磺酰基，Ts-dpm；R = 丹磺酰基，Ds-dpm；R = 7-硝基-1,2,3-苯并恶二唑，NBD -dpm) 已被合成和表征。这些配体与顺式-[Pt(DMSO) 2 Cl 2 ]（DMSO = 二甲基亚砜）在甲醇中的反应得到 [Pt(Ts-dpm)Cl 2 ] ( 1 ), [Pt(Ds-dpm)Cl 2 ] ( 2 ) 和 [Pt(NBD-dpm)Cl 2 ] ( 3）。这些配合物的晶体结构揭示了配体与具有非平面螯合环的 Pt 中心的双齿配位。由于配体的次甲基碳原子上有不等价的取代基，三种配合物中存在不同的外型和内型异构体。X 射线分析表明1以内构象结晶，2 以外构象结晶，3以两种构象异构体的混合物形式结晶。的1 H NMR和195复合物的 Pt NMR 谱显示了两组独立的信号，对应于化学上不等价的外型和内型构象异构体。外构象异构体通过
• Hydridodimethylplatinum(IV) Complexes with Bis(pyridine) Ligands:  Effect of Chelate Ring Size on Reactivity
  作者：Fenbao Zhang、Ernest M. Prokopchuk、Michael E. Broczkowski、Michael C. Jennings、Richard J. Puddephatt

  DOI：10.1021/om050982m

  日期：2006.3.1

  dimethylplatinum(II) complexes [PtMe2(LL)] has been studied, by comparing complexes with the ligands LL = di-2-pyridylamine (DPA) or di-2-pyridyl ketone (DPK), which form a six-membered chelate ring, to compounds with 2,2‘-bipyridyl derivatives, which form a five-membered chelate ring. The complex [PtMe2(DPA)] undergoes easy oxidative addition of methyl iodide to give the corresponding platinum(IV) complex [PtIMe3(DPA)]

  通过与配体LL =二-2-吡啶胺（DPA）或配体进行比较，研究了改变二吡啶基配体LL的咬合角对二甲基铂（II）配合物[PtMe 2（LL）]的反应性的影响。形成六元螯合环的二-2-吡啶基酮（DPK）与具有五元螯合环的2,2'-联吡啶基衍生物的化合物。配合物[PtMe 2（DPA）]易于氧化碘甲烷，得到相应的铂（IV）配合物[PtIMe 3（DPA）]。[PtMe 2（DPA）]和[PtMe 2（DPK）]均在低温下被酸HX质子化，得到氢化二甲基铂（IV）络合物[PtHXMe 2（NN）]和[PtH（S）Me 2（NN）] X（S =溶剂），可以两种异构形式存在，H转化为X或N。配合物[PtHClMe 2（DPK）]的结构由晶体学确定。在含有过量CD 3 OD的溶液中，低温下会发生广泛的氢/氘交换成甲基铂基团和甲烷产物，这表明氢化甲基铂（IV）和（甲烷）铂（II）配合物之间的交换非常容易可逆。与NN
• Novel Platinum(II) Complexes with Dipyridyl Containing Chelating Ligands and their Products with the Model Nucleobases 1-Methylthymine and 1-Methyluracil
  作者：Ina Puscasu、Christian Mock、Michael Rauterkus、Axel Röndigs、Gesche Tallen、Suman Gangopadhyay、Johannes E. A. Wolff、Bernt Krebs

  DOI：10.1002/1521-3749(200106)627:6<1292::aid-zaac1292>3.0.co;2-p

  日期：2001.6

  [Pt2(dpma)2(1-MeT)2](ClO4)2 · H2O (5) and [Pt2(dpk)(dpk · H2O)(1-MeT)2](PF6)2 · 4 H2O (6) both show a head-to-head arrangement. Biological tests show a significant in vitro antitumor activity of [Pt(dpk)Cl2] against the human glioma cell line U 87. Platin(II)-Komplexe mit Dipyridyl-Ligandsystemen und ihre Produkte mit den Modell-Nukleobasen 1-Methylthymin und 1-Methyluracil Die Reaktionen von [Pt(dpma)(H2O)2]2+

  [Pt (dpma) (H2O) 2] 2+ (dpma = 2,2'-二吡啶基甲胺)和[Pt (dpk) ( ) 2] 2+ (dpk = 2,2'-二吡啶基酮)与研究了模型核碱基 1-甲基胸腺嘧啶 (1-MeT) 和 1-甲基尿嘧啶 (1-MeU)。反应产物通过 195 Pt NMR 光谱和 X 射线结构分析进行表征。对称的 dpma 和 dpk diaqua 复合物与 1-甲基胸腺嘧啶形成双核复合物，通过其 N3 和 O4 供体原子充当二级桥接配体。[Pt2 (dpma) 2 (1-MeT) 2] (ClO4) 2 · (5) 和 [Pt2 (dpk) (dpk · ) (1-MeT) 2] (PF6) 2 · 4 (6)两者都显示出头对头的安排。生物测试显示 [Pt (dpk) Cl2] 对人神经胶质瘤细胞系 U 87 具有显着的体外抗肿瘤活性。铂 (II)
• Influence of PtII and PdII coordination on the equilibrium of 2,2′-dipyridylketone (dpk) with its hydrated gem-diol form (dpk·H2O)
  作者：Anupam Khutia、Pablo J. Sanz Miguel、Bernhard Lippert

  DOI：10.1016/j.ica.2010.02.035

  日期：2010.10

  2,2'-Dipyridylketone (dpk), when acting as a chelating ligand for Pd-II or Pt-II, is in slow equilibrium with its corresponding gem-diol form (dpk center dot H2O). In D2O, equilibrium constants K = (dpk center dot H2O)/(dpk) change from ca. 0.04 for the free ligand to ca. 3 in the corresponding complexes with cis-[Pt(H2O)(2)](2+). In solution, species of both ligands can be identified and differentiated by H-1 NMR spectroscopy, and in the trinuclear mu-OH bridged Pt-II complex [Pt-3(mu-OH)(3)(dpk center dot H2O)(2)(dpk)](NO3)(3)center dot 4.5H(2)O (4), both types of ligands are present simultaneously in a ratio of (dpk center dot H2O):(dpk) = 2. As demonstrated with a series of Pd-II complexes containing dpk center dot H2O and dpk ligands, a straightforward differentiation is possible when DMSO-d(6) is used as solvent, because then also the OH protons of dpk center dot H2O are observable. It is also shown that monocrystalline [PdCl2(dpk center dot H2O)] (1), when dissolved in DMSO-d(6), partially converts, with loss of H2O, to [PdCl2(dpk)]. (C) 2010 Elsevier B. V. All rights reserved.
• Joshi; Gijare, Journal of the Indian Chemical Society, 1989, vol. 66, # 7, p. 474 - 475
  作者：Joshi、Gijare

  DOI：——

  日期：——