4-(7-(4-aminophenoxy)thieno[3,2-b]pyridin-2-yl)phenol | 875340-20-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(7-(4-aminophenoxy)thieno[3,2-b]pyridin-2-yl)phenol
• 英文别名: 4-[7-(4-aminophenoxy)thieno[3,2-b]pyridin-2-yl]phenol
• CAS: 875340-20-8
• 化学式: C₁₉H₁₄N₂O₂S
• 分子量: 334.398
• InChiKey: BOZFIRLEHILZEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(7-(4-aminophenoxy)thieno[3,2-b]pyridin-2-yl)phenol 、 N-(3-fluoro-4-(2-(4-hydroxyphenyl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide 以title compound 200 was obtained in 3% yield的产率得到N-(4-(2-(4-hydroxyphenyl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide
  参考文献：
  名称：

  Inhibitors of VEGF Receptor and HGF Receptor Signalling

  摘要：

  本发明涉及抑制VEGF受体信号和HGF受体信号的方法。本发明提供了抑制VEGF受体信号和HGF受体信号的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。

  公开号：

  US20100216766A1
• 作为产物：
  描述：

  4-(7-(4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)phenol 、 4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)phenol 以title compound 199 was obtained in 83% yield的产率得到4-(7-(4-aminophenoxy)thieno[3,2-b]pyridin-2-yl)phenol
  参考文献：
  名称：

  Inhibitors of VEGF Receptor and HGF Receptor Signalling

  摘要：

  本发明涉及抑制VEGF受体信号和HGF受体信号的方法。本发明提供了抑制VEGF受体信号和HGF受体信号的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。

  公开号：

  US20100216766A1

文献信息

• INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING
  申请人：Saavedra Mario Oscar

  公开号：US20060287343A1

  公开（公告）日：2006-12-21

  The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

  本发明涉及抑制VEGF受体信号和HGF受体信号的方法。本发明提供了抑制VEGF受体信号和HGF受体信号的化合物和方法。本发明还提供了用于治疗细胞增殖性疾病和病状的组合物和方法。
• Inhibitors of VEGF receptor and HGF receptor signaling
  申请人：Vaisburg Arkadii

  公开号：US20060074056A1

  公开（公告）日：2006-04-06

  The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

  本发明涉及抑制VEGF受体信号和HGF受体信号的方法。本发明提供了抑制VEGF受体信号和HGF受体信号的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病状的组合物和方法。
• Substituted thieno[3,2-d]pyridines as inhibitors of the VEGF receptor and HGF receptor
  申请人：Methylgene Inc.

  公开号：US07772247B2

  公开（公告）日：2010-08-10

  The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

  本发明涉及抑制VEGF受体信号和HGF受体信号的技术。本发明提供了用于抑制VEGF受体信号和HGF受体信号的化合物和方法。本发明还提供了用于治疗细胞增殖性疾病和病状的组合物和方法。
• Inhibitors of VEGF Receptor and HGF Receptor Signaling
  申请人：Saavedra Oscar Mario

  公开号：US20100249145A1

  公开（公告）日：2010-09-30

  The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

  本发明涉及抑制VEGF受体信号和HGF受体信号的技术。本发明提供了用于抑制VEGF受体信号和HGF受体信号的化合物和方法。本发明还提供了用于治疗细胞增殖性疾病和情况的组合物和方法。
• Inhibitors of VEGF receptor and HGF receptor signalling
  申请人：Vaisburg Arkadii

  公开号：US08470850B2

  公开（公告）日：2013-06-25

  The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

  本发明涉及抑制VEGF受体信号和HGF受体信号的方法。本发明提供了抑制VEGF受体信号和HGF受体信号的化合物和方法。本发明还提供了用于治疗细胞增殖性疾病和病况的组合物和方法。