(2-imino-4,5,6,7-tetrahydro-benzothiazol-3-yl)-acetic acid ethyl ester | 769065-42-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2-imino-4,5,6,7-tetrahydro-benzothiazol-3-yl)-acetic acid ethyl ester
• 英文别名: Ethyl 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)acetate
• CAS: 769065-42-1
• 化学式: C₁₁H₁₆N₂O₂S
• 分子量: 240.326
• InChiKey: WGMBXZGSIWTDSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  78.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  苯甲醛 、 (2-imino-4,5,6,7-tetrahydro-benzothiazol-3-yl)-acetic acid ethyl ester 在 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 生成 3-benzylidene-5,6,7,8-tetrahydro-benzo[d]imidazo[2,1-b]thiazol-2-one
  参考文献：
  名称：

  Synthesis and biological properties of ylidene derivatives of thiazol[3,2-a]imidazol-6-one

  摘要：

  DOI：

  10.1007/bf00779293
• 作为产物：
  描述：

  4,5,6,7-四氢苯并噻唑-2-胺 、 氯乙酸乙酯 以 乙醇 为溶剂， 反应 16.0h， 生成 (2-imino-4,5,6,7-tetrahydro-benzothiazol-3-yl)-acetic acid ethyl ester
  参考文献：
  名称：

  Synthesis and biological properties of ylidene derivatives of thiazol[3,2-a]imidazol-6-one

  摘要：

  DOI：

  10.1007/bf00779293

文献信息

• Compounds having activity as inhibitors of apoptosis
  申请人：Cottam B. Howard

  公开号：US20060122178A1

  公开（公告）日：2006-06-08

  The present invention provides compounds that can protect mammalian cells from the damaging effects of chemotherapy, irradiation, or in other situations in which it is desirable to protect tissue from the consequences of clinical or environmental stress.

  本发明提供了一种化合物，可以保护哺乳动物细胞免受化疗、辐射或其他情况的损害，其中希望保护组织免受临床或环境应激的后果。
• TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS
  申请人：Greig Nigel H

  公开号：US20080319032A1

  公开（公告）日：2008-12-25

  This invention relates generally to tetrahydrobenzothiazole analogues and tetrahydrobenzooxyzole analogues, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to methods of treatment using these compounds. The invention also encompasses pharmaceutically acceptable esters, amides, and salts of such compounds. The invention further provides a method of reducing or delaying apoptosis in a population of cells, comprising contacting the population of cells with a tetrahydrobenzothiazole analogue or a tetrahydrobenzooxyzole analogue, thereby reducing or delaying apoptosis in the population of cells.

  本发明涉及四氢苯并噻唑类似物和四氢苯并噁唑类似物，以及包括这些化合物和药用可接受载体的制药组合物和使用这些化合物的治疗方法。本发明还包括这些化合物的药用可接受酯、酰胺和盐。本发明还提供一种减少或延迟细胞群体凋亡的方法，包括将细胞群体与四氢苯并噻唑类似物或四氢苯并噁唑类似物接触，从而减少或延迟细胞群体的凋亡。
• US7601846B2
  申请人：——

  公开号：US7601846B2

  公开（公告）日：2009-10-13
• [EN] TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS<br/>[FR] AGENTS NEUROPROTECTEURS À BASE D'ANALOGUES DE TÉTRAHYDROBENZOTHIAZOLE
  申请人：US GOV HEALTH & HUMAN SERV

  公开号：WO2002004409A2

  公开（公告）日：2002-01-17

  This invention relates generally to tetrahydrobenzothiazole analogues and tetrahydrobenzooxyzole analogues, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to methods of treatment using these compounds. The invention also encompasses pharmaceutically acceptable esters, amides, and salts of such compounds. The invention further provides a method of reducing or delaying apoptosis in a population of cells, comprising contacting the population of cells with a tetrahydrobenzothiazole analogue or a tetrahydrobenzooxyzole analogue, thereby reducing or delaying apoptosis in the population of cells.
• Synthesis and biological properties of ylidene derivatives of thiazol[3,2-a]imidazol-6-one
  作者：A. N. Krasovskii、E. I. Bogatyreva、I. I. Soroka、P. M. Kochergin、N. P. Grin'

  DOI：10.1007/bf00779293

  日期：1977.6