2-deoxy-2-[¹⁸F]fluoro-myo-inositol | 1402463-99-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-deoxy-2-[¹⁸F]fluoro-myo-inositol
• CAS: 1402463-99-3
• 化学式: C₆H₁₁FO₅
• 分子量: 181.15
• InChiKey: PDTJJYSBSOKEOY-SQOQKJAGSA-N

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 、 sodium hydroxide 作用下， 以 水 、 乙腈 为溶剂， 反应 0.5h， 生成 2-deoxy-2-[¹⁸F]fluoro-myo-inositol
  参考文献：
  名称：

  Radiosynthesis and in vivo tumor uptake of 2-deoxy-2-[18F]fluoro-myo-inositol

  摘要：

  Inositols play an important role in membrane lipid metabolism and mitogenic signaling of most cancer cells. There is paucity of data on the distribution of radiolabelled inositols. Based on work previously carried out on 1-deoxy-1-[F-18]fluoro-scyllo-inositol ([F-18]2), we began a program of work to label myo-inositol (2-deoxy-2-[F-18]fluoro-myo-inositol, [F-18]1), the most abundant inositol in cells. Fluorination of a triflate precursor 4 afforded the desired [F-18]1 following deprotection with a radiochemical yield of 8% n.d.c. [F-18]1 showed higher uptake in vivo in a human breast cancer xenograft model, MDA-MB-231, compared to [F-18]2. Thus, we have developed a new inositol radiotracer that could have utility for studying inositol uptake in tumors. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.022