N⁶-benzyl-O^2'-methyl-adenosine | 133077-93-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: N⁶-benzyl-O^2'-methyl-adenosine
• 英文别名: (2R,5R)-5-[6-(benzylamino)purin-9-yl]-2-(hydroxymethyl)-4-methoxyoxolan-3-ol
• CAS: 133077-93-7
• 化学式: C₁₈H₂₁N₅O₄
• 分子量: 371.396
• InChiKey: UXZVWFZQQVJPSO-UZFJHYNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Adenosine derivatives having pharmaceutical activity as antihypertensives
  申请人：NIPPON ZOKI PHARMACEUTICAL CO. LTD.

  公开号：EP0378518A2

  公开（公告）日：1990-07-18

  The present invention relates to novel adenosine derivatives having the formula (I): wherein R is a lower alkyl group; R′ is hydrogen or a lower alkyl group; X is a cycloalkyl group, an alkyl group having at least one hydroxy group, an alkyl group having at least one phenyl group, a bicycloalkyl group, a naphthylalkyl group, an acenaphthylenylalkyl group or a group of the formula (II) or (III); Z is hydrogen, a hydroxy group or a lower alkoxy group, Q is hydrogen or a hydroxy group, A is -CH₂-, -O-, -S- or represents a direct bond and Y is -­(CH₂)n- or represents a direct bond and n is an integer of 1 to 3; and the broken line represents an optional bond and pharmaceutically acceptable salts thereof, which are useful as antihypertensive agents.

  本发明涉及具有式(I)的新型腺苷衍生物： 其中 R 是低级烷基；R′是氢或低级烷基；X 是环烷基、至少有一个羟基的烷基、至少有一个苯基的烷基、双环烷基、萘烷基、苊烯基或式 (II) 或 (III) 的基团； Z 是氢、羟基或低级烷氧基，Q 是氢或羟基，A 是-CH₂-、-O-、-S- 或代表直接键，Y 是-(CH₂)n- 或代表直接键，n 是 1 至 3 的整数；断线代表任选键。 及其药学上可接受的盐，可用作降压药。
• Adenosindeaminase inhibitor
  申请人：NIPPON ZOKI PHARMACEUTICAL CO., LTD.

  公开号：EP0601322A2

  公开（公告）日：1994-06-15

  The use of a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof wherein each of R₁, R₂ and R₃ which may be same or different is hydrogen or alkyl; and R and X have the meanings given in the specification, for the preparation of a medicament which is an adenosinedeaminase inhibitor is disclosed. Some of the compounds of formula (I) are novel compounds. They may be used for the making of a medicament which is for the prevention or therapy of ischemic heart diseases, diseases caused by cerebrovascular disorders, renal diseases and allergic diseases and of post-operative complicated diseases involved with activated oxygen which is generated in ischemic areas during the recirculation of blood after operations.

  使用以下通式（I）代表的化合物或其药学上可接受的盐 其中R₁、R₂和R₃可以相同或不同，各自为氢或烷基；R和X具有说明书中给出的含义。一些式（I）化合物是新型化合物。它们可用于制备预防或治疗缺血性心脏病、脑血管疾病、肾脏疾病和过敏性疾病以及术后复杂疾病的药物，这些疾病与术后血液再循环过程中在缺血区域产生的活性氧有关。