3-(4-Methoxy-phenyl)-3-(4-methoxy-phenylamino)-1-phenyl-propan-1-one | 119948-38-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(4-Methoxy-phenyl)-3-(4-methoxy-phenylamino)-1-phenyl-propan-1-one
• 英文别名: 3-(4-Methoxyanilino)-3-(4-methoxyphenyl)-1-phenylpropan-1-one
• CAS: 119948-38-8
• 化学式: C₂₃H₂₃NO₃
• 分子量: 361.441
• InChiKey: XKYJPQFOYLBAOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基苯甲醛 在 potassium phosphate 作用下， 以 乙醇 为溶剂， 反应 1.67h， 生成 3-(4-Methoxy-phenyl)-3-(4-methoxy-phenylamino)-1-phenyl-propan-1-one
  参考文献：
  名称：

  K3PO4-catalyzed one-pot synthesis of β-amino ketones

  摘要：

  A new strategy which uses cheap K3PO4 as a very effective catalyst has been developed for synthesis of beta-amino ketones by one-pot reaction of an aryl aldehyde, acetophenone derivative, and amine in EtOH at room temperature.

  DOI：

  10.1007/s00706-012-0729-1

文献信息

• Bi(NO3)3•5H2O: An Efficient and Green Catalyst for Synthesis of 1,5-Benzodiazepines and b-Amino Carbonyl Compounds
  作者：Jaspreet Kaur Rajput、Gagandeep Kaur

  DOI：10.14233/ajchem.2013.14353

  日期：——

  Bismuth nitrate pentahydrate is found to be an efficient catalyst for the synthesis of 1,5-benzodiazepines and b-amino carbonyl compounds using condensation of o-phenylenediamine with ketones and one pot three component Mannich reaction, respectively under solvent free conditions at room temperature. This method offers a simple, solvent free, room temperature, environment friendly synthesis of 1,5-benzodiazepines and b-amino carbonyl compounds. The products are isolated by column chromatography and recrystallization, respectively and were characterized by their melting point, IR and 1H NMR spectroscopy.

  五水合硝酸铋被发现是一种高效的催化剂，可在无溶剂、室温条件下分别通过邻苯二胺与酮的缩合反应以及一锅法三组分曼尼希反应合成1,5-苯二氮杂卓和β-氨基羰基化合物。这种方法提供了一种简单、无溶剂、室温、环境友好的合成1,5-苯二氮杂卓和β-氨基羰基化合物的方式。产物分别通过柱层析和重结晶进行分离，并利用熔点、红外光谱和核磁共振氢谱进行表征。
• Natural phosphate and potassium fluoride doped natural phosphate: efficient catalysts for the construction of a carbon–nitrogen bond
  作者：Mohamed Zahouily、Bouchaib Bahlaouan、Ahmed Rayadh、Saı̈d Sebti

  DOI：10.1016/j.tetlet.2004.03.164

  日期：2004.5

  phosphates doped with potassium fluoride as heterogeneous catalysts for the Michael addition of aromatic and aliphatic amines to α,β-unsaturated carbonyl compounds is presented. The natural phosphate catalyst can be regenerated and reused without loss of activity, which makes it an attractive alternative to homogeneous basic reagents. Doping natural phosphate with potassium fluoride significantly enhances

  提出了掺有氟化钾的天然磷酸盐作为多相催化剂在芳族和脂肪族胺向α，β-不饱和羰基化合物的迈克尔加成中的应用。天然磷酸盐催化剂可以再生和再利用而不会损失活性，这使其成为均质碱性试剂的有吸引力的替代品。用氟化钾掺杂天然磷酸酯可显着提高反应速度和收率。
• 3‐Aminoindole Synthesis from 2‐Nitrochalcones and Ammonia or Primary Amines
  作者：Guan Zhang、Lu Lin、Kai Yang、Shihui Wang、Qiang Feng、Jun Zhu、Qiuling Song

  DOI：10.1002/adsc.201900551

  日期：2019.8.21

  A step‐economic strategy for 3‐aminoindoles synthesis with ammonia or primary amines as “N” source under transition‐metal‐free conditions was achieved. A series of 3‐aminoindoles was obtained with abundant “N” source featuring high efficiency, mild conditions, environmental friendliness and scalability. Efficient syntheses of the intermediates of COX‐2 inhibitor and tubulin polymerization inhibitor

  在无过渡金属的条件下，实现了以氨或伯胺为“ N”源的3-氨基吲哚合成的分步经济策略。获得了一系列3-氨基吲哚，其中含有丰富的“ N”源，具有高效率，温和的条件，环境友好性和可扩展性。通过这种新开发的策略，成功完成了COX-2抑制剂和微管蛋白聚合抑制剂中间体的高效合成。
• Aminolysis of para-substituted benzalacetophenones
  作者：El Sayed M. E. Mansour、Samir K. El-Sadany、Ahmed A. Kassem、Hamdy A. Maksoud

  DOI：10.1021/je00057a030

  日期：1989.7
• MANSOUR, EL-SAYED M. E.;EL-SADANY, SAMIR K.;KASSEM, AHMED A.;MAKSOUD, HAM+, J. CHEM. AND ENG. DATA, 34,(1989) N, C. 368-370
  作者：MANSOUR, EL-SAYED M. E.、EL-SADANY, SAMIR K.、KASSEM, AHMED A.、MAKSOUD, HAM+

  DOI：——

  日期：——