N6-[1''-(4''-trifluoroacetamidobutyl)]-5'-O-mesyladenosine | 871793-13-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: N6-[1''-(4''-trifluoroacetamidobutyl)]-5'-O-mesyladenosine
• CAS: 871793-13-4
• 化学式: C₁₇H₂₃F₃N₆O₇S
• 分子量: 512.467
• InChiKey: WWGUKIPYAHOHMC-SDBHATRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.71
• 重原子数：
  34.0
• 可旋转键数：
  10.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  177.79
• 氢给体数：
  4.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  乙烯亚胺 、 N6-[1''-(4''-trifluoroacetamidobutyl)]-5'-O-mesyladenosine 在 N,N-二异丙基乙胺 作用下， 反应 72.0h， 生成
  参考文献：
  名称：

  Sequence-specific Methyltransferase-Induced Labelling (SMILing) of plasmid DNA for studying cell transfection

  摘要：

  Plasmid DNA (pUC19 and pBR322) was sequence-specifically, covalently labelled with Cy3 fluorophores using a newly synthesised N-adenosylaziridine cofactor and the DNA methyltransferase M.TaqI. The fluorescently labelled plasmids were used for transfection of mammalian cells and their intracellular distribution was visualised by epifluorescence and confocal fluorescence microscopy. Although these prokaryotic plasmids do not contain nuclear import sequences, translocation into the nuclei was observed. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.04.054
• 作为产物：
  描述：

  N6-[1''-(4''-trifluoroacetamidobutyl)]-2,'3'-O-isopropylidene-5'-O-mesyladenosine 在 甲酸 作用下， 反应 72.0h， 以96%的产率得到N6-[1''-(4''-trifluoroacetamidobutyl)]-5'-O-mesyladenosine
  参考文献：
  名称：

  Sequence-specific Methyltransferase-Induced Labelling (SMILing) of plasmid DNA for studying cell transfection

  摘要：

  Plasmid DNA (pUC19 and pBR322) was sequence-specifically, covalently labelled with Cy3 fluorophores using a newly synthesised N-adenosylaziridine cofactor and the DNA methyltransferase M.TaqI. The fluorescently labelled plasmids were used for transfection of mammalian cells and their intracellular distribution was visualised by epifluorescence and confocal fluorescence microscopy. Although these prokaryotic plasmids do not contain nuclear import sequences, translocation into the nuclei was observed. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.04.054