1,4-bis(3-(4-methoxyphenyl)-4-(4-chlorophenylsulfonyl)-isoxazol-5-yl)benzene | 1563186-29-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-bis(3-(4-methoxyphenyl)-4-(4-chlorophenylsulfonyl)-isoxazol-5-yl)benzene
• 英文别名: 4-(4-Chlorophenyl)sulfonyl-5-[4-[4-(4-chlorophenyl)sulfonyl-3-(4-methoxyphenyl)-1,2-oxazol-5-yl]phenyl]-3-(4-methoxyphenyl)-1,2-oxazole；4-(4-chlorophenyl)sulfonyl-5-[4-[4-(4-chlorophenyl)sulfonyl-3-(4-methoxyphenyl)-1,2-oxazol-5-yl]phenyl]-3-(4-methoxyphenyl)-1,2-oxazole
• CAS: 1563186-29-7
• 化学式: C₃₈H₂₆Cl₂N₂O₈S₂
• 分子量: 773.671
• InChiKey: UXGMZSFYNZZWGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  52
• 可旋转键数：
  10
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  156
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  (4-氯苯磺酰基)乙酸 在 chloramine T trihydrate 、 四氯苯醌 、 苄胺 作用下， 以 甲醇 、 5,5-dimethyl-1,3-cyclohexadiene 、 溶剂黄146 为溶剂， 生成 1,4-bis(3-(4-methoxyphenyl)-4-(4-chlorophenylsulfonyl)-isoxazol-5-yl)benzene
  参考文献：
  名称：

  Synthesis and antimicrobial activity of (1,4-phenylene)bis(arylsulfonylpyrazoles and isoxazoles)

  摘要：

  A new class of (1,4-phenylene)bis(arylsufonylpyrazoles and isoxazoles) were synthesized by 1,3-dipolar cycloaddition of nitrile imines and nitrile oxides to the 1,4-bis((E)-2-(arylsulfonyl)vinyl)benzenes in the presence of chloramine-T. Compound 7f exhibited pronounced antimicrobial activity. Crown Copyright (C) 2013 Published by Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.11.041

文献信息

• Synthesis and antimicrobial activity of (1,4-phenylene)bis(arylsulfonylpyrazoles and isoxazoles)
  作者：G. Lavanya、L. Mallikarjuna Reddy、V. Padmavathi、A. Padmaja

  DOI：10.1016/j.ejmech.2013.11.041

  日期：2014.2

  A new class of (1,4-phenylene)bis(arylsufonylpyrazoles and isoxazoles) were synthesized by 1,3-dipolar cycloaddition of nitrile imines and nitrile oxides to the 1,4-bis((E)-2-(arylsulfonyl)vinyl)benzenes in the presence of chloramine-T. Compound 7f exhibited pronounced antimicrobial activity. Crown Copyright (C) 2013 Published by Elsevier Masson SAS. All rights reserved.