per-O-acetyl-per-6-azido-per-6-deoxy-3^I-O-formylmethyl-β-cyclodextrin | 1415579-10-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: per-O-acetyl-per-6-azido-per-6-deoxy-3^I-O-formylmethyl-β-cyclodextrin
• CAS: 1415579-10-0
• 化学式: C₇₀H₉₁N₂₁O₄₂
• 分子量: 1898.61
• InChiKey: VUUAKDZVWYVEHU-DCBUKTJTSA-N

反应信息

• 作为产物：
  描述：

  per-O-acetyl-per-6-azido-per-6-deoxy-3^I-O-cinnamyl-β-cyclodextrin 在 臭氧 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 0.33h， 以67%的产率得到per-O-acetyl-per-6-azido-per-6-deoxy-3^I-O-formylmethyl-β-cyclodextrin
  参考文献：
  名称：

  Synthesis of 3I-O and 2I-O-monosubstituted derivatives of per-6-azido-β-cyclodextrin—potential molecular scaffolds

  摘要：

  Alkylation of per-6-azido-beta-cyclodextrin by a suitable electrophilic reagent (cinnamyl bromide or propargyl bromide) gave a mixture of 3(I)-O and 2(I)-O regioisomers. After peracetylation and chromatographic separation on silica gel, pure isomers were isolated. Oxidative cleavage of cinnamyl double bond afforded the corresponding formylmethyl and carboxymethyl derivatives. The prepared scaffold molecules are equipped with two types of reactive groups which have a potential to serve as points of attachment for various compounds. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2012.09.003