3-(4-chlorophenylthio)-3-(2-hydroxyphenyl)-1-phenylpropan-1-one | 1423579-82-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(4-chlorophenylthio)-3-(2-hydroxyphenyl)-1-phenylpropan-1-one
• 英文别名: 3-(4-Chlorophenyl)sulfanyl-3-(2-hydroxyphenyl)-1-phenylpropan-1-one；3-(4-chlorophenyl)sulfanyl-3-(2-hydroxyphenyl)-1-phenylpropan-1-one
• CAS: 1423579-82-1
• 化学式: C₂₁H₁₇ClO₂S
• 分子量: 368.884
• InChiKey: LQFCRLDQFPIAJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-hydroxychalcone 、 4-氯苯硫酚 以 甲苯 为溶剂， 反应 0.25h， 生成 3-(4-chlorophenylthio)-3-(2-hydroxyphenyl)-1-phenylpropan-1-one
  参考文献：
  名称：

  Catalyst-free C–S/C–O bond formation: synthesis of novel 4-thio-substituted 2-aryl-4H-chromenes from easily available 2-hydroxychalcones

  摘要：

  An efficient catalyst-free synthesis of novel functionalized 4-thio-substituted 2-aryl-4H-chromenes from easily available 2-hydroxychalcone derivatives is described. This domino reaction enables successful assembly of two new C-S and C-O sigma bonds in a one-pot operation. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.01.047

文献信息

• Catalyst-free C–S/C–O bond formation: synthesis of novel 4-thio-substituted 2-aryl-4H-chromenes from easily available 2-hydroxychalcones
  作者：Guo-Dong Yin、Ting-Ting Lai、Zhi-Si Yan、Han Chen、Jing Zheng、Qing Tao

  DOI：10.1016/j.tet.2013.01.047

  日期：2013.3

  An efficient catalyst-free synthesis of novel functionalized 4-thio-substituted 2-aryl-4H-chromenes from easily available 2-hydroxychalcone derivatives is described. This domino reaction enables successful assembly of two new C-S and C-O sigma bonds in a one-pot operation. (c) 2013 Elsevier Ltd. All rights reserved.