Dimethylamino-9-(3-desoxyβ-d-erythro-pentofuranosyl)-purin | 3608-59-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: Dimethylamino-9-(3-desoxyβ-d-erythro-pentofuranosyl)-purin
• 英文别名: 6-Dimethylamino-9-(3'-deoxy-β-D-ribofuranosyl)purin；3'-Deoxy-N⁶-dimethyladenosin；N⁶,N⁶-dimethyl-3'-deoxy-adenosine；(2R,3R,5S)-2-(6-(Dimethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol；(2R,3R,5S)-2-[6-(dimethylamino)purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol
• CAS: 3608-59-1
• 化学式: C₁₂H₁₇N₅O₃
• 分子量: 279.299
• InChiKey: VDYVUSHAIIBDOB-JOAULVNJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  96.5
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] NEW MOLECULES FOR ISOLATION OF POLYRIBOSOMES, RIBOSOMES, USES AND KITS THEREOF<br/>[FR] NOUVELLES MOLÉCULES POUR L'ISOLATION DE POLYRIBOSOMES, RIBOSOMES, UTILISATIONS ET KITS ASSOCIÉS
  申请人：IMMAGINA BIOTECHNOLOGY S R L

  公开号：WO2017013547A1

  公开（公告）日：2017-01-26

  Molecules of general Formula (I): able to bind to native polyribosomes engaged in active protein synthesis. The disclosure relates also to the use of the molecules of general Formula (I) for isolating at least one active ribosome from a biological sample, and for ribosome profiling, as well as kits for isolating at least one active ribosome from a biological sample.

  通用式（I）的分子能够结合到参与活跃蛋白质合成的原生多核体上。该公开还涉及使用通用式（I）的分子从生物样本中分离至少一个活跃核糖体，并用于核糖体剖析，以及用于从生物样本中分离至少一个活跃核糖体的工具包。
• ONE-POT PREPARATION PROCESS FOR ANTIBODY DRUG CONJUGATE INTERMEDIATE
  申请人：Mabplex International, Ltd.

  公开号：EP3760233A1

  公开（公告）日：2021-01-06

  The present invention relates to a "one-pot process" for preparing intermediate of antibody-drug conjugate. The preparation process provided by the present invention is simple in operation, and needs no such steps like concentration, washing and filtration of the intermediate reaction liquid, disposal of the organic waste liquid, and packaging and storage of the intermediate. The entire reaction system comprises only one separation and purification treatment, saving costs for labor, equipment, venues, raw materials, etc., and greatly reducing the pollution to the environment. In addition, the "one-pot process" for preparing intermediate of antibody-drug conjugate of the present invention produces the intermediate of antibody-drug conjugate with higher yield. The "one-pot process" for preparing intermediate of antibody-drug conjugate provided by the present invention is more suitable for scale-up production.

  本发明涉及一种制备抗体药物共轭物中间体的 "一锅法"。本发明提供的制备工艺操作简单，无需中间体反应液的浓缩、洗涤、过滤，有机废液的处理，中间体的包装和储存等步骤。整个反应系统只需一次分离提纯处理，节省了人工、设备、场地、原料等成本，大大减少了对环境的污染。此外，本发明制备抗体药物共轭物中间体的 "一锅法 "生产的抗体药物共轭物中间体收率更高。本发明提供的制备抗体药物共轭物中间体的 "一锅法 "更适合规模化生产。
• NEW MOLECULES FOR ISOLATION OF POLYRIBOSOMES, RIBOSOMES, USES AND KITS THEREOF
  申请人：Immagina Biotechnology S.r.l.

  公开号：EP3324972B1

  公开（公告）日：2019-10-02