7-Deacetoxy-14,15-deoxy-1,2-dihydro-7-oxo-gedunin | 23638-88-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子
• 英文名称: 7-Deacetoxy-14,15-deoxy-1,2-dihydro-7-oxo-gedunin
• 英文别名: (1R,4bR,10aS,12aR)-1-(furan-3-yl)-4b,7,7,10a,12a-pentamethyl-1,6,6a,9,10,10b,11,12-octahydronaphtho[2,1-f]isochromene-3,5,8-trione
• CAS: 23638-88-2
• 化学式: C₂₆H₃₂O₅
• 分子量: 424.537
• InChiKey: QETWTNOFHMQEHW-LUKAEVKMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  73.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Methods of Identifying and Using General or Alternative Splicing Inhibitors
  申请人：Dreyfuss Gideon

  公开号：US20120157474A1

  公开（公告）日：2012-06-21

  The present invention is based on the discovery of a cell-based system to identify novel modulators of splicing or splicing dependent processes. The cell-based system of the present invention utilizes a fast and highly sensitive reporter, that responds to defects in the splicing machinery itself and is sensitive to changes in the signals that regulate splicing dependent processes such as those that modulate the EJC, splicing-dependent export, localization or translation efficiency. The present invention further uses the cell-based screen to identify several small molecules that modulate both constitutive and alternative splicing. Accordingly, the present invention includes general or alternative splicing inhibitors identified using the assay described herein. The present invention also provides methods of treating a subject having a condition associated with aberrant target RNA expression. The present invention further details a kit that may be directed to specifically detecting a general or alternative splicing inhibitor of the invention.