1-(4-fluoro-phenyl)-3-{4-[2-(methyl(pyridin-2-yl)amino)-ethoxy]-phenyl}-propen-1-one | 1259288-31-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(4-fluoro-phenyl)-3-{4-[2-(methyl(pyridin-2-yl)amino)-ethoxy]-phenyl}-propen-1-one
• CAS: 1259288-31-7
• 化学式: C₂₃H₂₁FN₂O₂
• 分子量: 376.43
• InChiKey: QFXFZRNCYFNDKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.63
• 重原子数：
  28.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  42.43
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-(4-fluoro-phenyl)-3-{4-[2-(methyl(pyridin-2-yl)amino)-ethoxy]-phenyl}-propen-1-one 在 盐酸羟胺 、 potassium carbonate 作用下， 以 异丙醇 为溶剂， 反应 2.0h， 生成 1-(4-fluoro-phenyl)-3-{4-[2-(methyl(pyridin-2-yl)amino)-ethoxy]-phenyl}-propen-1-one oxime
  参考文献：
  名称：

  Synthesis of 4-[2-(methyl-2-pyridin-2yl-amino)-ethoxy]-benzaldehyde derivatives

  摘要：

  Several 2,4-thiazolidindiones were prepared from corresponding aryl aldehydes by Knovengel condensation between Aldehydes and 2,4-thiazolidindione which shows anti-hyperglycemic potency such as Pioglitazone and Rosiglitazone. In our attempt we have prepared 4-[2-(methyl-2-pyridin-2yl-amino)-ethoxy]-benzaldehyde derivatives. Condensation of aryl Aldehydes with aryl ketones by Aldol condensation and the derivatives may have comparable biological importance.

  DOI：

  10.1515/hc.2010.16.1.47
• 作为产物：
  描述：

  2-氯吡啶 在 potassium hydroxide 、 sodium hydroxide 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 10.0h， 生成 1-(4-fluoro-phenyl)-3-{4-[2-(methyl(pyridin-2-yl)amino)-ethoxy]-phenyl}-propen-1-one
  参考文献：
  名称：

  Synthesis of 4-[2-(methyl-2-pyridin-2yl-amino)-ethoxy]-benzaldehyde derivatives

  摘要：

  Several 2,4-thiazolidindiones were prepared from corresponding aryl aldehydes by Knovengel condensation between Aldehydes and 2,4-thiazolidindione which shows anti-hyperglycemic potency such as Pioglitazone and Rosiglitazone. In our attempt we have prepared 4-[2-(methyl-2-pyridin-2yl-amino)-ethoxy]-benzaldehyde derivatives. Condensation of aryl Aldehydes with aryl ketones by Aldol condensation and the derivatives may have comparable biological importance.

  DOI：

  10.1515/hc.2010.16.1.47