N-[(3,7-dimethyltricyclo[3.3.0.0(3,7)]oct-1-yl)methyl]guanidine hydrochloride | 1100308-16-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[(3,7-dimethyltricyclo[3.3.0.0(3,7)]oct-1-yl)methyl]guanidine hydrochloride
• CAS: 1100308-16-4
• 化学式: C₁₂H₂₁N₃*ClH
• 分子量: 243.78
• InChiKey: AXXUWDIDDSUHDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.11
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  61.9
• 氢给体数：
  3.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  [(3,7-dimethyltricyclo[3.3.1.0(3,7)]oct-1-yl)methyl]amine hydrochloride 、 1H-吡唑-1-甲脒盐酸盐 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 30.0h， 以77%的产率得到N-[(3,7-dimethyltricyclo[3.3.0.0(3,7)]oct-1-yl)methyl]guanidine hydrochloride
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs

  摘要：

  The synthesis of several (3-noradamantyl)amines, [(3-noradamantyl)methyl]amines, (3,7-dimethyl-1-bisnoradamantyl)amines, and [(3,7-dimethyl-1-bisnoradamantyl)methyl]amines is reported. They were evaluated against a wide range of viruses and one of them inhibited the cytopathicity of influenza A virus at a concentration similar to that of amantadine. Several of the new polycyclic amines show an interesting activity as NMDA receptor antagonists. A rimantadine analogue displayed significant trypanocidal activity. Moreover, to further characterize the pharmacology of these compounds, their effects on dopamine uptake were also assessed. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.10.028