4-乙基-3-甲基吡啶 | 20815-29-6

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4-乙基-3-甲基吡啶
• 中文别名: 3-甲基-4-乙基吡啶
• 英文名称: 3-Methyl-4-ethyl-pyridin
• 英文别名: 4-Ethyl-3-methylpyridin；4-Ethyl-β-picolin；3-methyl-4-ethyl-pyridine；4-Ethyl-3-methylpyridine
• CAS: 20815-29-6
• 化学式: C₈H₁₁N
• mdl: MFCD00014636
• 分子量: 121.182
• InChiKey: NJQZTGGQYUUYKS-UHFFFAOYSA-N

物化性质

• 沸点：
  192-193 °C
• 密度：
  0.9485 g/cm3
• 保留指数：
  1104

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  4-乙基-3-甲基吡啶 在 palladium on activated charcoal 硫酸 、 溴 、 一水合肼 、 calcium carbonate 作用下， 以 乙醇 为溶剂， 反应 12.0h， 生成 4-(4-Ethyl-3-methyl-pyridin-2-yl)-morpholine
  参考文献：
  名称：

  Dunn, Allan D.; Blais, Mickael, Zeitschrift fur Chemie, 1989, vol. 29, # 8, p. 287 - 288

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(2,5-Dimethyl-pyrrol-1-yl)-4-ethyl-3-methyl-1,4-dihydro-pyridine 在 偶氮二异丁腈 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以77%的产率得到4-乙基-3-甲基吡啶
  参考文献：
  名称：

  Katritzky, Alan R.; Beltrami, Hector; Sammes, Michael P., Journal of Chemical Research, Miniprint, 1981, # 5, p. 1684 - 1696

  摘要：

  DOI：

文献信息

• [EN] PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS<br/>[FR] PYRROLOTRIAZINES EN TANT QU'INHIBITEURS D'ALK ET DE JAK2
  申请人：CEPHALON INC

  公开号：WO2010071885A1

  公开（公告）日：2010-06-24

  The present invention provides a compound of formula (I) or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula (I) has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.

  本发明提供了一种式（I）的化合物或其盐形式，其中Q1、Q2、Q3和Q4如本文所定义。式（I）的化合物具有ALK和/或JAK2抑制活性，并可用于治疗增殖性疾病。
• Pyridine derivatives and insecticide and miticide comprising said
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：US05262420A1

  公开（公告）日：1993-11-16

  A pyridine compound of the formula ##STR1## wherein X is a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxyl group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 4 carbon atoms or a haloalkoxyl group having 1 to 4 carbon atoms, n is 1 to 5, and when n is 2 or more, Xs may be identical to or different from each other, A is an alkyl residue or alkene residue in which a portion connecting the aryl group with the 4-position of the pyridyl group has 3 to 8 carbon atoms, or an alkapolyene residue in which said portion has 4 to 8 carbon atoms and 2 to 4 double bonds; the alkyl residue, alkene residue, and alkapolyene residue may have an alkyl side chain having 1 to 4 carbon atoms, an alkylidene side chain having 1 to 4 carbon atoms or 1 to 16 halogen atoms, and when there are 2 or more side chains, the side chains may be identical to or different from each other, and R.sup.1 and R.sup.2 are each a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or salts thereof. The pyridine compounds and salts thereof exhibit a strong insecticidal and miticidal activity and are low in residuality and accumulativity and are thus useful as insecticides and miticides for the control of pests in agriculture and horticulture.

  一种杂环化合物，其分子式为##STR1##，其中X为氢原子、卤素原子、1至4个碳原子的烷基、1至4个碳原子的烷氧基、1至4个碳原子的卤代烷基或1至4个碳原子的卤代烷氧基；n为1至5，当n为2个或更多时，X可以相同也可以不同；A为连接芳基和吡啶基4位的部分含有3至8个碳原子的烷基残基或烯基残基，或含有4至8个碳原子和2至4个双键的烯丙基残基；烷基残基、烯基残基和烯丙基残基可以含有1至4个碳原子的烷基侧链、1至4个碳原子或1至16个卤素原子的亚烷基侧链，当存在2个或更多侧链时，侧链可以相同也可以不同；R1和R2各自为氢原子或含有1至6个碳原子的烷基，或其盐。这些杂环化合物及其盐类具有强烈的杀虫和杀螨活性，且残留性和积累性低，因此作为杀虫剂和杀螨剂用于农业和园艺中控制害虫非常有用。
• Catalytic reactions of pyridines. VI. Heterogeneous vapor-phase ring alkylation of pyridines with alcohols over H+-, Li+-, and alkaline earth cation-exchanged zeolites.
  作者：HIROSHI KASHIWAGI、YUJI FUJIKI、SABURO ENOMOTO

  DOI：10.1248/cpb.30.2575

  日期：——

  The heterogeneous vapor-phase alkylation of pyridine with methanol was examined over metal cation-exchanged X-and Y-type zeolites in an atmosphere of nitrogen. β-Methylation was observed over H+-or Li+-exchanged zeolites, whereas α-and γ-methylation (the former occurred in preference) were observed over alkaline earth cation-exchanged zeolites. For example, at 400°C, the yields of α-, β-, and γ-picolines over the HY catalyst were 2.6, 12.2, and 2.6%, whereas those over the BaY catalyst were 22.7, 3.8, and 7.6%, respectively. This catalytic ring alkylation over metal cation-exchanged zeolites was also examined by the use of pyridine with ethanol and picolines with either methanol or ethanol.

  在氮气气氛下，通过金属阳离子交换的X型和Y型沸石，研究了吡啶与甲醇的非均相气相烷基化反应。在H+或Li+交换的沸石上观察到β-甲基化，而在碱土金属阳离子交换的沸石上观察到α-和γ-甲基化（前者优先发生）。例如，在400°C时，HY催化剂上的α-、β-和γ-甲基吡啶的产率分别为2.6%、12.2%和2.6%，而BaY催化剂上的产率分别为22.7%、3.8%和7.6%。还通过使用乙醇与吡啶以及甲醇或乙醇与吡啶同系物研究了金属阳离子交换沸石上的这种催化环烷基化反应。
• IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES
  申请人：Stange Hans

  公开号：US20100120763A1

  公开（公告）日：2010-05-13

  The invention relates to imidazo[5,1-c][1,2,4]benzotriazine derivatives of formula I: which are inhibitors of phosphodiesterase 2 or 10 useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type 2 diabetes, metabolic syndrome, glucose intolerance, and pain.

  本发明涉及式I的咪唑并[5,1-c][1,2,4]苯并三嗪衍生物：它们是磷酸二酯酶2或10的抑制剂，可用于治疗精神病等中枢神经系统疾病，以及例如肥胖、2型糖尿病、代谢综合征、葡萄糖耐受不良和疼痛。
• [EN] AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS<br/>[FR] THIAZOLES À SUBSTITUTION AMIDE UTILISÉS EN TANT QU'INHIBITEURS DE LA SÉCRÉTINE PROTÉIQUE
  申请人：KEZAR LIFE SCIENCES

  公开号：WO2019046668A1

  公开（公告）日：2019-03-07

  Provided herein are thiazole carboxamide protein secretin inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I): and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.

  本文提供了噻唑羧酰胺蛋白质分泌抑制剂，例如Sec61的抑制剂，其制备方法，相关的药物组合物，以及使用这些物质的方法。例如，本文提供了化合物的公式（I）：及其药用盐和包含这些化合物的组合物。本文披露的化合物可以用于治疗炎症和/或癌症等疾病。

表征谱图