2-benzyloxy-5-chlorophenyl formate | 1189360-81-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-benzyloxy-5-chlorophenyl formate
• 英文别名: formic acid, 2-benzyloxy-5-chloro-phenyl ester；formic acid 2-benzyloxy-5-chloro-phenyl ester；(5-chloro-2-phenylmethoxyphenyl) formate
• CAS: 1189360-81-3
• 化学式: C₁₄H₁₁ClO₃
• 分子量: 262.693
• InChiKey: BYDMNOODAYGJHY-UHFFFAOYSA-N

物化性质

• 沸点：
  385.7±42.0 °C(Predicted)
• 密度：
  1.266±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-benzyloxy-5-chlorophenyl formate 在 potassium carbonate 、 sodium hydroxide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.5h， 生成 3-(2-benzyloxy-5-chlorophenoxy)-1,2-epoxypropane
  参考文献：
  名称：

  Benzodioxane–benzamides as new bacterial cell division inhibitors

  摘要：

  A SAR study was performed on 3-substituted 2,6-difluorobenzamides, known inhibitors of the essential bacterial cell division protein FtsZ, through a series of modifications first of 2,6-difluoro-3-nonyloxybenzamide and then of its 3-pyridothiazolylmethoxy analogue PC190723. The study led to the identification of chiral 2,6-difluorobenzamides bearing 1,4-benzodioxane-2-methyl residue at the 3-position as potent antistaphylococcal compounds. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.09.100
• 作为产物：
  描述：

  2-(苄氧基)-5-氯苯甲醛 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 生成 2-benzyloxy-5-chlorophenyl formate
  参考文献：
  名称：

  PROCESS FOR PREPARATION OF BENZO-FUSED HETEROARYL DERIVATIVES

  摘要：

  本发明涉及用于制备苯并杂环衍生物的方法，用于治疗癫痫和相关疾病。本发明还涉及用于制备苯并杂环衍生物合成中间体的方法。

  公开号：

  US20090247618A1

文献信息

• PROCESS FOR PREPARATION OF BENZO-FUSED HETEROARYL DERIVATIVES
  申请人：Ballentine Scott A.

  公开号：US20090247618A1

  公开（公告）日：2009-10-01

  The present invention is directed to processes for the preparation of benzo-fused heteroaryl derivatives, useful for the treatment of epilepsy and related disorders. The present invention is further directed to processes for the preparation of intermediates in the synthesis of the benzo-fused heteroaryl derivatives.

  本发明涉及用于制备苯并杂环衍生物的方法，用于治疗癫痫和相关疾病。本发明还涉及用于制备苯并杂环衍生物合成中间体的方法。
• [EN] PROCESSES FOR THE PREPARATION OF BENZO-FUSED DIOXIN DERIVATIVES<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION DE DÉRIVÉS D'HÉTÉROARYLE BENZO-CONDENSÉS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009120192A3

  公开（公告）日：2010-01-21
• [EN] PROCESS FOR THE PREPARATION OF BENZO-FUSED HETEROARYL DERIVATIVES<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION DE DÉRIVÉS D'HÉTÉROARYLE BENZO-CONDENSÉS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009120192A2

  公开（公告）日：2009-10-01

  The present invention is directed to processes for the preparation of benzo-fused heteroaryl derivatives, useful for the treatment of epilepsy and related disorders. The present invention is further directed to processes for the preparation of intermediates in the synthesis of the benzo-fused heteroaryl derivatives.
• [EN] NOVEL MODULATORS OF EHMT1 AND EHMT2 AND THERAPEUTIC USE THEREOF<br/>[FR] NOUVEAUX MODULATEURS DE L'EHMT1 ET DE L'EHMT2 ET LEUR UTILISATION THÉRAPEUTIQUE
  申请人：[en]TANGO THERAPEUTICS, INC.

  公开号：WO2023064586A1

  公开（公告）日：2023-04-20

  Described herein are novel compounds, compositions and methods for modulating EHMT1 and EHMT2 and treatment of diseases including cancer using such compounds, compositions, and methods.
• Benzodioxane–benzamides as new bacterial cell division inhibitors
  作者：Giuseppe Chiodini、Marco Pallavicini、Carlo Zanotto、Massimiliano Bissa、Antonia Radaelli、Valentina Straniero、Cristiano Bolchi、Laura Fumagalli、Paola Ruggeri、Carlo De Giuli Morghen、Ermanno Valoti

  DOI：10.1016/j.ejmech.2014.09.100

  日期：2015.1

  A SAR study was performed on 3-substituted 2,6-difluorobenzamides, known inhibitors of the essential bacterial cell division protein FtsZ, through a series of modifications first of 2,6-difluoro-3-nonyloxybenzamide and then of its 3-pyridothiazolylmethoxy analogue PC190723. The study led to the identification of chiral 2,6-difluorobenzamides bearing 1,4-benzodioxane-2-methyl residue at the 3-position as potent antistaphylococcal compounds. (C) 2014 Elsevier Masson SAS. All rights reserved.