4-[3-phenyl-4-(2-thienyl)-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]benzenesulfonamide | 1219689-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[3-phenyl-4-(2-thienyl)-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]benzenesulfonamide
• 英文别名: 4-[3-Phenyl-4-thiophen-2-yl-6-(trifluoromethyl)pyrazolo[3,4-b]pyridin-1-yl]benzenesulfonamide
• CAS: 1219689-73-2
• 化学式: C₂₃H₁₅F₃N₄O₂S₂
• 分子量: 500.525
• InChiKey: FJNQUBJTKMRNJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  4-肼基苯磺酰胺 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 4-[3-phenyl-4-(2-thienyl)-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]benzenesulfonamide
  参考文献：
  名称：

  Synthesis and anti-inflammatory evaluation of some pyrazolo[3,4-b]pyridines

  摘要：

  Novel series of pyrazolo[3,4-b]pyridines with basic skeleton different from the known COX inhibitors were synthesized from 5-amino-1-[4-(aminosulfonyl)phenyl]-3-phenyl-1H-pyrazole, which in turn was prepared by the condensation of (4-sulfamoylphenyl)hydrazine with alpha-cyanoacetophenone. All the newly synthesized compounds were tested for their in vivo anti-inflammatory activity by carrageenan-induced rat paw edema assay. Some of the most potent compounds were evaluated in different COX and LOX assays. Some of the new compounds were found to possess moderate anti-inflammatory activity.

  DOI：

  10.1007/s00044-010-9312-7